Cloned (Comment) | Organism |
---|---|
overexpression of type 3 17beta-HSD in HEK-293 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | design, synthesis and in vitro evaluation of 4-androstene-3,17-dione/adenosine hybrid compounds as bisubstrate inhibitors of type 3 17beta-HSD, the bisubstrate inhibitors are less potent in intact cells than in homogenated cells, overview, the best inhibitors of that series are those bearing an alkyl side-chain spacer of 11 or 12 methylenes with inhibition of 69% and 78% at 1 mM | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme is an important therapeutic target for androgen-sensitive diseases, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-androstene-3,17-dione + NADPH + H+ | selective reduction at C17 | Homo sapiens | testosterone + NADP+ | - |
? | |
additional information | the enzyme is an important therapeutic target for androgen-sensitive diseases, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
17beta-HSD | - |
Homo sapiens |
type 3 17beta-HSD | - |
Homo sapiens |
type 3 17beta-hydroxysteroid dehydrogenase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |