Cloned (Comment) | Organism |
---|---|
expression in Sf9 insect cells | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
hanging-drop vapour diffusion method at 27°C, crystallization of the enzyme in complex with estrone and NADP+. His221 is the key residue responsible for the reorganization and stabilization of the reversely bound estrone, leading to the formation of a dead end complex, which exists widely in NADP(H)-preferred enzymes for the regulation of their enzymatic activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
estrone | substrate inhibition | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P14061 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
ovary | the enzyme is primarily expressed in the placenta and ovarian granulose cells | Homo sapiens | - |
placenta | the enzyme is primarily expressed in the placenta and ovarian granulose cells | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
17beta-HSD1 | - |
Homo sapiens |
17beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme catalyses the last step in estrogen activation | Homo sapiens |
physiological function | the enzyme is involved in estrogen-dependent diseases | Homo sapiens |