Application | Comment | Organism |
---|---|---|
diagnostics | a high HSD17B1 to HSD17B2 ratio, as well as high HSD17B1 on its own is associated with worse prognosis and increased risk of recurrence in patients with ERalpha-positive tumors. An increased copy number of the HSD17B1 gene is correlated with decreased breast cancer survival | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P14061 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dehydroepiandrosterone + NAD(P)H + H+ | - |
Homo sapiens | androstendiol + NAD(P)+ | - |
? | |
estrone + NAD(P)H + H+ | - |
Homo sapiens | 17beta-estradiol + NAD(P)+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
17beta-HSD1 | - |
Homo sapiens |
17beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | in non-small cell lung cancer (NSCLC) the expression of HSD17B1 is increased as compared with healthy tissue | up |
General Information | Comment | Organism |
---|---|---|
drug target | the ratio of HSD17B1 to HSD17B2 is a good indicator of tamoxifen treatment benefit, as post-menopausal patients with tumors expressing a high HSD17B1/HSD17B2 protein ratio have less benefit from tamoxifen treatment | Homo sapiens |
physiological function | the expression of 17beta-hydroxysteroid dehydrogenase 1 and 2 alone and in combination predicts outcome of patients with breast cancer | Homo sapiens |