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Literature summary for 1.1.1.53 extracted from
- Comparison of the 3alpha-and 20beta-hydroxysteroid dehydrogenase activities of the cortisone reductase of Streptomyces hydrogenans (1978), Biochemistry, 17, 4370-4376.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Streptomyces exfoliatus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 16alpha-Bromoacetoxyprogesterone | - |
Streptomyces exfoliatus |  |
| 17beta-Bromoacetoxyandrostan-3-one | - |
Streptomyces exfoliatus | |
| Cortisone 21-iodoacetate | in absence of NADH, slight | Streptomyces exfoliatus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0028 | - |
progesterone | - |
Streptomyces exfoliatus | |
| 0.009 | 0.01 | NADH | - |
Streptomyces exfoliatus | |
| 0.024 | - |
cortisone | - |
Streptomyces exfoliatus | |
| 0.14 | - |
3,20-Dioxo-4-pregnen-21-oic acid | 17beta-hydroxyandrostan-3-one | Streptomyces exfoliatus | |
| 0.46 | - |
17beta-hydroxyandrostan-2-one | - |
Streptomyces exfoliatus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces exfoliatus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| no glycoprotein | - |
Streptomyces exfoliatus |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Streptomyces exfoliatus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | - |
Streptomyces exfoliatus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 17beta-hydroxyandrostan-2-one + NADH + H+ | - |
Streptomyces exfoliatus | ? | - |
r | |
| 3,20-dioxo-4-pregnen-21-oic acid + NADH | - |
Streptomyces exfoliatus | 20beta-hydroxy-3-oxo-4-pregnen-21-oic acid + NAD+ | - |
? | |
| cortisone + NAD(P)H | - |
Streptomyces exfoliatus | 17alpha,20beta,21-trihydroxy-pregn-4-ene-3,11-dione + NAD(P)+ | - |
? | |
| progesterone + NAD(P)H | - |
Streptomyces exfoliatus | 20beta-hydroxy-pregn-4-ene-3-one + NAD(P)+ | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | - |
Streptomyces exfoliatus | |
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Release 2023.1 (January 2023)
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