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Literature summary for 1.1.1.53 extracted from

  • Tokarz, J.; Lintelmann, J.; Moeller, G.; Adamski, J.
    Substrate multispecificity among 20?-hydroxysteroid dehydrogenase type 2 members (2020), Mol. Cell. Endocrinol., 510, 110822 .
    View publication on PubMed
Search for more literature for 1.1.1.53

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000142
-
 cortisone 28°C, pH not specified in the publication Danio rerio

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Danio rerio 5783
-

Organism

Organism UniProt Comment Textmining
Danio rerio
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo th enzyme is expressed throughout the whole embryonic development Danio rerio
-
gill high expression Danio rerio
-
gonad high expression Danio rerio
-
intestine high expression Danio rerio
-
kidney high expression Danio rerio
-
liver high expression Danio rerio
-
additional information in adult tissues 20beta-HSD type 2 shows a ubiquitous expression pattern with some minor sex-specific differences Danio rerio
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cortisone + NADPH + H+ no activity with NAD+ Danio rerio 20beta-hydroxycortisone + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
20beta-HSD type 2
-
 Danio rerio
20beta-hydroxysteroid dehydrogenase type 2
-
 Danio rerio
SDR12C55
-
 Danio rerio

Cofactor

Cofactor Comment Organism Structure
NADP+ no activity with NAD+ Danio rerio

General Information

General Information Comment Organism
metabolism the enzyme mediates glucocorticoid catabolism in fish, important enzyme in cortisol catabolism Danio rerio