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Literature summary for 1.1.1.62 extracted from
- On the mitochondrial 17beta-hydroxysteroid dehydrogenase from human endometrium and endometrial carcinoma: characterization and intramitochondrial distribution (1976), J. Steroid Biochem., 7, 45-50.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Cu2+ | 1 mM, 82% inhibition | Homo sapiens |  |
| iodoacetamide | 1 mM, 78% inhibition | Homo sapiens | |
| Mg2+ | 1 mM, 18% inhibition | Homo sapiens | |
| PCMB | 1 mM, complete inhibition | Homo sapiens | |
| Zn2+ | 1 mM, 33% inhibition | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0032 | - |
estradiol-17beta | cosubstrate NADP+, secretory endometrium | Homo sapiens | |
| 0.0036 | - |
estradiol | cosubstrate NAD+, secretory endometrium | Homo sapiens | |
| 0.0128 | - |
estradiol-17beta | cosubstrate NADP+, proliferating endometrium | Homo sapiens | |
| 0.0134 | - |
estradiol | cosubstrate NAD+, proliferating endometrium | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrial outer membrane | - |
Homo sapiens | 5741 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| uterine endometrium | proliferative | Homo sapiens | - |
| uterine endometrium | secretory | Homo sapiens | - |
| uterine endometrium | endometrial carcinoma | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-androstene-3,17-dione + NADPH + H+ | - |
Homo sapiens | testosterone + NADP+ | - |
r | |
| androstenedione + NADPH + H+ | 50% of the activity with estradiol-17beta | Homo sapiens | testosterone + NADP+ | - |
? | |
| estradiol-17beta + NAD+ | - |
Homo sapiens | estrone + NADH | - |
r | |
| estradiol-17beta + NADP+ | - |
Homo sapiens | estrone + NADPH | - |
r | |
| estrone + NADH | - |
Homo sapiens | estradiol-17beta + NAD+ | - |
r | |
| estrone + NADPH + H+ | - |
Homo sapiens | estradiol-17beta + NADP+ | - |
r | |
| testosterone + NADP+ | 75% of the activity with estradiol-17beta | Homo sapiens | 4-androstene-3,17-dione + NADPH + H+ | - |
r | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 45 | - |
enzyme from crude washed mitochondria | Homo sapiens |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 24 | 54 | 24°C: about 60% of maximal activity, 54°C: about 50% of maximal activity, enzyme from crude washed mitochondria | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | - |
reduction of estrone | Homo sapiens |
| 9.5 | - |
oxidation of estradiol-17beta | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | cofactor | Homo sapiens | |
| NADH | cofactor | Homo sapiens | |
| NADP+ | cofactor | Homo sapiens | |
| NADPH | cofactor | Homo sapiens | |
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