KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0033 | - |
estradiol-17beta | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
uterine endometrium | secretory | Homo sapiens | - |
uterine endometrium | endometrial carcinoma | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
androstenedione + NADPH + H+ | - |
Homo sapiens | testosterone + NADP+ | - |
r | |
estradiol-17beta + NAD+ | - |
Homo sapiens | estrone + NADH | - |
r | |
estradiol-17beta + NADP+ | maximal activity with NADP+ is approximately 1/3 of that with NAD+ | Homo sapiens | estrone + NADPH | - |
r | |
estrone + NADH | - |
Homo sapiens | estradiol-17beta + NAD+ | - |
r | |
estrone + NADPH + H+ | - |
Homo sapiens | estradiol-17beta + NADP+ | - |
r | |
testosterone + NADP+ | - |
Homo sapiens | 4-androstene-3,17-dione + NADPH + H+ | androstenedione | r |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
40 | - |
oxidation of estradiol-17beta | Homo sapiens |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
additional information | - |
enzyme is cold sensitive, cold inactivation is reduced by NAD+, NADP+, estradiol or glycerol | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | - |
reduction of estrone | Homo sapiens |
9.5 | - |
oxidation of estradiol-17beta | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | cofactor | Homo sapiens | |
NAD+ | maximal activity with NADP+ is approximately 1/3 of that with NAD+ | Homo sapiens | |
NADH | cofactor | Homo sapiens | |
NADP+ | cofactor | Homo sapiens | |
NADP+ | maximal activity with NADP+ is approximately 1/3 of that with NAD+ | Homo sapiens | |
NADPH | cofactor | Homo sapiens |