Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli as an enzymatically active His-tag fusion protein | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0464 | - |
testosterone | 37°C, pH 7.4 | Homo sapiens | |
0.118 | - |
estradiol | 37°C, pH 7.4 | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
32000 | - |
x * 32000, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
cerebellum | - |
Homo sapiens | - |
heart | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
kidney | high expression | Homo sapiens | - |
liver | - |
Homo sapiens | - |
lung | - |
Homo sapiens | - |
ovary | - |
Homo sapiens | - |
placenta | - |
Homo sapiens | - |
placenta | high expression | Homo sapiens | - |
prostate | - |
Homo sapiens | - |
prostate | high expression | Homo sapiens | - |
small intestine | - |
Homo sapiens | - |
stomach | - |
Homo sapiens | - |
testis | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-androstene-3beta,17beta-diol + NAD+ | 5.9% of the activity with estradiol | Homo sapiens | 5-androstene-3-beta-ol-17-one + NADH | - |
? | |
5alpha-dihydrotestosterone + NAD+ | 3.2% of the activity with estradiol | Homo sapiens | 5alpha-androstan-3,17-dione + NADH + H+ | - |
? | |
estradiol-17beta + NAD+ | enzyme catalyzes the reduction of estrone to estradiol, the rate is 2.3% of the activity with estradiol | Homo sapiens | estrone + NADH + H+ | - |
? | |
testosterone + NAD+ | 2.4% of the activity with estradiol | Homo sapiens | 4-androstene-3,17-dione + NADH + H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 32000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
17beta-HSD type 8 | - |
Homo sapiens |
17beta-hydroxysteroid dehydrogenase type 8 | - |
Homo sapiens |