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Literature summary for 1.1.1.62 extracted from

  • Brozic, P.; Kocbek, P.; Sova, M.; Kristl, J.; Martens, S.; Adamski, J.; Gobec, S.; Lanisnik Rizner, T.
    Flavonoids and cinnamic acid derivatives as inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (2009), Mol. Cell. Endocrinol., 301, 229-234.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21-CodonPlus (DE3)-RIL cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(2Z,2'E)-N,N'-1H-1,5-benzodiazepine-2,4-diylbis(3-phenylprop-2-enamide) 30% inhibition at 0.006 mM Homo sapiens
2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl (2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoate 44% inhibition at 0.006 mM Homo sapiens
2-nitrophenyl (2E)-3-phenylprop-2-enoate 45% inhibition at 0.006 mM Homo sapiens
3,4,5-trimethoxycinnamic acid
-
Homo sapiens
3-(trifluoromethyl)-cinnamic acid
-
Homo sapiens
3-phenoxybenzyl (2E)-3-(1,3-benzodioxol-5-yl)prop-2-enoate 14% inhibition at 0.006 mM Homo sapiens
3-phenoxybenzyl (2E)-3-phenylprop-2-enoate 13% inhibition at 0.006 mM Homo sapiens
4'-cyanophenyl 3,4-methylenedioxycinnamate
-
Homo sapiens
4-(octanoylamino)phenyl (2E)-3-phenylprop-2-enoate 15% inhibition at 0.006 mM Homo sapiens
4-cyanophenyl (2E)-3-(1,3-benzodioxol-5-yl)prop-2-enoate 76% inhibition at 0.006 mM Homo sapiens
6-hydroxyflavone 53.3% inhibition at 0.006 mM Homo sapiens
7,4'-Dihydroxyflavone more than 90% inhibition at 0.006 mM Homo sapiens
baicalein i.e. 5,6,7-trihydroxyflavone, 61% inhibition at 0.006 mM Homo sapiens
benzyl (2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoate 60% inhibition at 0.006 mM Homo sapiens
benzyl (2E)-3-phenylprop-2-enoate 35% inhibition at 0.006 mM Homo sapiens
chrysoeriol i.e. 4',5,7-trihydroxy-3'-methoxyflavone, 82% inhibition at 0.006 mM Homo sapiens
Cinnamic acid
-
Homo sapiens
coumarin-3-carboxylic acid
-
Homo sapiens
cyclohexyl (2E)-3-phenylprop-2-enoate 25% inhibition at 0.006 mM Homo sapiens
diosmetin i.e. 3',5,7-trihydroxy-4'-methoxyflavone, more than 90% inhibition at 0.006 mM Homo sapiens
eupatorin 37% inhibition at 0.006 mM Homo sapiens
fisetin 72% inhibition at 0.006 mM Homo sapiens
genkwanin 3',5-dihydroxy-7-methoxyflavone, 81% inhibition at 0.006 mM Homo sapiens
m-coumaric acid
-
Homo sapiens
myricetin i.e. 3,3',4',5',5,7-hexahydroxyflavone, 52% inhibition at 0.006 mM Homo sapiens
naphthalen-2-yl (2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoate 56% inhibition at 0.006 mM Homo sapiens
p-aminocinnamic acid
-
Homo sapiens
p-carboxycinnamic acid
-
Homo sapiens
p-nitro-cinnamic acid
-
Homo sapiens
phenyl (2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoate 35% inhibition at 0.006 mM Homo sapiens
scutellarein i.e. 4',5,6,7-tetrahydroxyflavone, 88% inhibition at 0.006 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P14061
-
-

Source Tissue

Source Tissue Comment Organism Textmining
T-47D cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
estradiol-17beta + NADP+
-
Homo sapiens estrone + NADPH + H+
-
r

Synonyms

Synonyms Comment Organism
17beta-HSD1
-
Homo sapiens
17beta-hydroxysteroid dehydrogenase type 1
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Homo sapiens