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Literature summary for 1.1.1.62 extracted from

  • Muthusamy, S.; Andersson, S.; Kim, H.J.; Butler, R.; Waage, L.; Bergerheim, U.; Gustafsson, J.A.
    Estrogen receptor beta and 17beta-hydroxysteroid dehydrogenase type 6, a growth regulatory pathway that is lost in prostate cancer (2011), Proc. Natl. Acad. Sci. USA, 108, 20090-20094.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.62

Application

Application Comment Organism
medicine isoform 17betaHSD6 is expressed in estrogen receptor beta-positive epithelial cells of the human prostate. In prostate cancers of Gleason grade higher than 3, both estrogen receptor beta and isoform 17betaHSD6 are undetectable Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O14756 isoform 17betaHSD6
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Source Tissue

Source Tissue Comment Organism Textmining
additional information in prostate cancers of Gleason grade higher than 3, both estrogen receptor beta and isoform 17betaHSD6 are undetectable Homo sapiens
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prostate expressed in estrogen receptor beta-positive epithelial cells of the human prostate Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5alpha-dihydrotestosterone + NADPH + H+
-
 Homo sapiens 5alpha-androstane-3beta,17beta-diol + 5alpha-androstane-3,17-dione + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
17beta-hydroxysteroid dehydrogenase type 6
-
 Homo sapiens
17betaHSD6
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function 17beta-hydroxysteroid dehydrogenase type 6 converts the androgen 5alpha-dihydrotestosterone to the estrogen 5alpha-androstane-3beta,17beta-diol, and this leads to activation of the estrogen receptor beta reporter. This conversion of dihydrotestosterone occurs at concentrations that are in the physiological range of this hormone in the prostate Homo sapiens