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Literature summary for 1.1.1.62 extracted from

  • Shikina, S.; Chung, Y.J.; Chiu, Y.L.; Huang, Y.J.; Lee, Y.H.; Chang, C.F.
    Molecular cloning and characterization of a steroidogenic enzyme, 17beta-hydroxysteroid dehydrogenase type 14, from the stony coral Euphyllia ancora (Cnidaria, Anthozoa) (2016), Gen. Comp. Endocrinol., 228, 95-104.
    View publication on PubMed
Search for more literature for 1.1.1.62

Cloned(Commentary)

Cloned (Comment) Organism
gene 17beta-Hsd 14, DNA and amino acid sequence determinnation and analysis, sequence comparisns and phylogenetic analysis and tree, quantitative RT-PCR expression analysis Fimbriaphyllia ancora

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
17beta-estradiol + NAD+ Fimbriaphyllia ancora
-
 estrone + NADH + H+
-
 r

Organism

Organism UniProt Comment Textmining
Fimbriaphyllia ancora A0A0G2SJM3
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endoderm
-
 Fimbriaphyllia ancora
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gonad
-
 Fimbriaphyllia ancora
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mesenterial filament
-
 Fimbriaphyllia ancora
-
additional information enzyme identified from transcriptomic analysis. Lack of correlation of Ea17beta-hsd 14 transcript levels with the coral's reproductive cycle. Ea17beta-hsd 14 transcript and protein are detected in all tissues examined, such as the tentacles, mesenterial filaments, and gonads, at similar levels in both sexes, as determined by quantitative RT-PCR analysis and Western blotting with an anti-Ea17beta-Hsd 14 antibody. Immunohistochemical analysis reveals that Ea17beta-Hsd 14 is mainly distributed in the endodermal regions of the polyps, but the protein is also observed in all tissues examined. Seasonal variation in the levels of Ea17beta-hsd 14 transcripts, overview Fimbriaphyllia ancora
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tentacle
-
 Fimbriaphyllia ancora
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17beta-estradiol + NAD+
-
 Fimbriaphyllia ancora estrone + NADH + H+
-
 r

Synonyms

Synonyms Comment Organism
17beta-hsd 14
-
 Fimbriaphyllia ancora
17beta-hydroxysteroid dehydrogenase type 14
-
 Fimbriaphyllia ancora

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Fimbriaphyllia ancora
NADH
-
 Fimbriaphyllia ancora

General Information

General Information Comment Organism
evolution 17beta-Hsd 14 from Euphyllia ancora clusters with other animal 17beta-HSD 14s but not with other members of the 17beta-HSD family Fimbriaphyllia ancora