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Literature summary for 1.1.1.62 extracted from

  • Salah, M.; Abdelsamie, A.S.; Frotscher, M.
    Inhibitors of 17?-hydroxysteroid dehydrogenase type 1, 2 and 14 Structures, biological activities and future challenges (2019), Mol. Cell. Endocrinol., 489, 66-81 .
    View publication on PubMed
Search for more literature for 1.1.1.62

Inhibitors

Inhibitors Comment Organism Structure
additional information 17beta-HSD1 and 17beta-HSD2 inhibitor structures and their biological activities are reviewed; 17beta-HSD1 and 17beta-HSD2 inhibitor structures and their biological activities are reviewed. Dual 17beta-HSD1/STS inhibitors and inhibitors are covered Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
estrogenic estrone + NAD(P)H + H+ Homo sapiens the product 17beta-estradiol plays a central role in the etiology of estrogen dependent diseases 17beta-estradiol + NAD(P)+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P14061
-
-
Homo sapiens P37059
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17beta-estradiol + NAD(P)+
-
 Homo sapiens estrone + NAD(P)H + H+
-
 ?
estrogenic estrone + NAD(P)H + H+ the product 17beta-estradiol plays a central role in the etiology of estrogen dependent diseases Homo sapiens 17beta-estradiol + NAD(P)+
-
 ?
estrone + NAD(P)H + H+
-
 Homo sapiens 17beta-estradiol + NAD(P)+
-
 ?

Synonyms

Synonyms Comment Organism
17beta-HSD1
-
 Homo sapiens
17beta-HSD2
-
 Homo sapiens
17beta-hydroxysteroid dehydrogenase type 1
-
 Homo sapiens
17beta-hydroxysteroid dehydrogenase type 2
-
 Homo sapiens