Literature summary for 1.1.1.88 extracted from

Li, T.; Liu, G.S.; Zhou, W.; Jiang, M.; Ren, Y.H.; Tao, X.Y.; Liu, M.; Zhao, M.; Wang, F.Q.; Gao, B.; Wei, D.Z.
Metabolic engineering of Saccharomyces cerevisiae to overproduce squalene (2020), J. Agric. Food Chem., 68, 2132-2138 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Saccharomyces cerevisiae strain SE5	Ruegeria pomeroyi

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+	Ruegeria pomeroyi	the enzyme is highly specific for NADH	(R)-mevalonate + CoA + 2 NAD+	-	?

Organism

Organism	UniProt	Comment	Textmining
Ruegeria pomeroyi	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+	the enzyme is highly specific for NADH	Ruegeria pomeroyi	(R)-mevalonate + CoA + 2 NAD+	-	?

Synonyms

Synonyms	Comment	Organism
3-hydroxy-3-methylglutaryl-coenzyme-A reductase	-	Ruegeria pomeroyi
HMG-CoA reductase	-	Ruegeria pomeroyi
NADH-HMGR	-	Ruegeria pomeroyi

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Ruegeria pomeroyi

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Release 2023.1 (January 2023)