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Literature summary for 1.1.1.93 extracted from
- Tartrate dehydrogenase catalyzes the stepwise oxidative decarboxylation of D-malate with both NAD and thio-NAD (2002), Biochemistry, 41, 12193-12199.
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | the reaction requires a divalent metal ion for activity | Escherichia coli |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (+)-tartrate + NAD+ | - |
Escherichia coli | oxaloglycolate + NADH + H+ | - |
? |  |
| D-malate + NAD+ | stepwise oxidative decarboxylation, a oxalacetate intermediate is formed | Escherichia coli | pyruvate + CO2 + NADH + H+ | - |
? | |
| D-malate + thio-NAD+ | - |
Escherichia coli | pyruvate + CO2 + thio-NADH + H+ | - |
? | |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
discussion of the pH-rate profile of the reaction with D-malate or (+)-tartrate, the pH dependence of the pyruvate/malate ratio is studied | Escherichia coli |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Escherichia coli | |
| thio-NAD+ | - |
Escherichia coli | |
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