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Literature summary for 1.1.1.95 extracted from

  • Kinoshita, M.O.; Shinoda, Y.; Sakai, K.; Hashikawa, T.; Watanabe, M.; Machida, T.; Hirabayashi, Y.; Furuya, S.
    Selective upregulation of 3-phosphoglycerate dehydrogenase (Phgdh) expression in adult subventricular zone neurogenic niche (2009), Neurosci. Lett., 453, 21-26.
    View publication on PubMed
Search for more literature for 1.1.1.95

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
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 Mus musculus
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Organism

Organism UniProt Comment Textmining
Mus musculus
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 adult male C57BL/6J mice
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Source Tissue

Source Tissue Comment Organism Textmining
brain enzyme expression in the subventricular neural progenitor cells, but not in differentiated neurons. The subventricular neural progenitor cells also show a decline in Phgdh expression in type B and C cells in the aged brain Mus musculus
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glial cell located in the rostral migratory stream, high enzyme expression level Mus musculus
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additional information tissue expression analysis, no expression in absent in committed neuronal precursors, type A cells, derived from type C cells Mus musculus
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neural stem cell primary culture Mus musculus
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primary culture
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 Mus musculus
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Synonyms

Synonyms Comment Organism
3-phosphoglycerate dehydrogenase
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 Mus musculus
Phgdh
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 Mus musculus

General Information

General Information Comment Organism
malfunction Phgdh null mice have markedly decreased free serine content in their tissues, which is associated with overall growth retardation, striking brain malformation, and embryonic lethality Mus musculus
metabolism 3-phosphoglycerate dehydrogenase catalyzes the first step of the phosphorylated pathway in the de novo synthesis of L-serine. Availability of L-serine within neural stem/progenitor cells may be a critical factor for neurogenesis in developing and adult brain Mus musculus
physiological function Phgdh null mice have markedly decreased free serine content in their tissues, which is associated with overall growth retardation, striking brain malformation, and embryonic lethality Mus musculus