Cloned (Comment) | Organism |
---|---|
gene aadh, DNA and amino acid sequence determination and analysis, expression analysis | Rhodococcus erythropolis |
Protein Variants | Comment | Organism |
---|---|---|
additional information | OrfE is a negative regulator that represses gene aadh expression in the absence of 1-amino-2-propanol. Construction of orfE disruption mutant and analysis of enzyme regulation in an OrfE-deficient mutant, overview | Rhodococcus erythropolis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2S)-2-(methylamino)-1-phenylpropan-1-one + NADPH + H+ | Rhodococcus erythropolis | - |
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol + NADP+ | i.e. D-pseudoephedrine | ? | |
(2S)-2-(methylamino)-1-phenylpropan-1-one + NADPH + H+ | Rhodococcus erythropolis MAK154 | - |
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol + NADP+ | i.e. D-pseudoephedrine | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rhodococcus erythropolis | A1IG83 | gene aadh | - |
Rhodococcus erythropolis MAK154 | A1IG83 | gene aadh | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2S)-2-(methylamino)-1-phenylpropan-1-one + NADPH + H+ | - |
Rhodococcus erythropolis | (1S,2S)-2-(methylamino)-1-phenylpropan-1-ol + NADP+ | i.e. D-pseudoephedrine | ? | |
(2S)-2-(methylamino)-1-phenylpropan-1-one + NADPH + H+ | - |
Rhodococcus erythropolis MAK154 | (1S,2S)-2-(methylamino)-1-phenylpropan-1-ol + NADP+ | i.e. D-pseudoephedrine | ? |
Synonyms | Comment | Organism |
---|---|---|
AADH | - |
Rhodococcus erythropolis |
NADP+-dependent aminoalcohol dehydrogenase | - |
Rhodococcus erythropolis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Rhodococcus erythropolis | |
NADPH | - |
Rhodococcus erythropolis |
Organism | Comment | Expression |
---|---|---|
Rhodococcus erythropolis | OrfE is a negative regulator that represses gene aadh expression in the absence of 1-amino-2-propanol | down |
Rhodococcus erythropolis | the enzyme is induced by the addition of several aminoalcohols, such as 1-amino-2-propanol | up |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme participates in aminoalcohol or aminoketone metabolism in the organism | Rhodococcus erythropolis |
additional information | OrfE is a negative regulator that represses gene aadh expression in the absence of 1-amino-2-propanol, analysis of enzyme regulation in tan OrfE-deficient mutant, overview | Rhodococcus erythropolis |