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Literature summary for 1.1.1.B18 extracted from

  • Urano, N.; Kataoka, M.; Ishige, T.; Kita, S.; Sakamoto, K.; Shimizu, S.
    Genetic analysis around aminoalcohol dehydrogenase gene of Rhodococcus erythropolis MAK154: a putative GntR transcription factor in transcriptional regulation (2011), Appl. Microbiol. Biotechnol., 89, 739-746.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene aadh, DNA and amino acid sequence determination and analysis, expression analysis Rhodococcus erythropolis

Protein Variants

Protein Variants Comment Organism
additional information OrfE is a negative regulator that represses gene aadh expression in the absence of 1-amino-2-propanol. Construction of orfE disruption mutant and analysis of enzyme regulation in an OrfE-deficient mutant, overview Rhodococcus erythropolis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(2S)-2-(methylamino)-1-phenylpropan-1-one + NADPH + H+ Rhodococcus erythropolis
-
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol + NADP+ i.e. D-pseudoephedrine ?
(2S)-2-(methylamino)-1-phenylpropan-1-one + NADPH + H+ Rhodococcus erythropolis MAK154
-
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol + NADP+ i.e. D-pseudoephedrine ?

Organism

Organism UniProt Comment Textmining
Rhodococcus erythropolis A1IG83 gene aadh
-
Rhodococcus erythropolis MAK154 A1IG83 gene aadh
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2S)-2-(methylamino)-1-phenylpropan-1-one + NADPH + H+
-
Rhodococcus erythropolis (1S,2S)-2-(methylamino)-1-phenylpropan-1-ol + NADP+ i.e. D-pseudoephedrine ?
(2S)-2-(methylamino)-1-phenylpropan-1-one + NADPH + H+
-
Rhodococcus erythropolis MAK154 (1S,2S)-2-(methylamino)-1-phenylpropan-1-ol + NADP+ i.e. D-pseudoephedrine ?

Synonyms

Synonyms Comment Organism
AADH
-
Rhodococcus erythropolis
NADP+-dependent aminoalcohol dehydrogenase
-
Rhodococcus erythropolis

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Rhodococcus erythropolis
NADPH
-
Rhodococcus erythropolis

Expression

Organism Comment Expression
Rhodococcus erythropolis OrfE is a negative regulator that represses gene aadh expression in the absence of 1-amino-2-propanol down
Rhodococcus erythropolis the enzyme is induced by the addition of several aminoalcohols, such as 1-amino-2-propanol up

General Information

General Information Comment Organism
metabolism the enzyme participates in aminoalcohol or aminoketone metabolism in the organism Rhodococcus erythropolis
additional information OrfE is a negative regulator that represses gene aadh expression in the absence of 1-amino-2-propanol, analysis of enzyme regulation in tan OrfE-deficient mutant, overview Rhodococcus erythropolis