Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3beta-hydroxy-11-oxo-18beta-olean-12-en-30-oic-acid | IC50: 0.254 mM; i.e. glycyrrhetinic acid | Cavia porcellus | |
chenodeoxycholic acid | IC50: 0.513 mM | Cavia porcellus | |
cholic acid | IC50: 3.529 mM | Cavia porcellus | |
Ethacrynic acid | IC50: 0.452 mM | Cavia porcellus | |
Furosemide | IC50: 0.059 mM, competitive | Cavia porcellus | |
naringenin | IC50: 0.336 mM | Cavia porcellus | |
naringin | IC50: 2.373 mM | Cavia porcellus | |
Phenylbutazone | IC50: 1.358 mM | Cavia porcellus | |
sistosterol | IC50: 1.395 mM | Cavia porcellus | |
stigmasterol | IC50: 1.968 mM | Cavia porcellus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.008 | - |
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione | i.e. cortisol | Cavia porcellus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+ | Cavia porcellus | i.e. cortisol | 17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH | i.e. cortisone | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cavia porcellus | - |
guinea pig | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | cortex | Cavia porcellus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+ | i.e. cortisol | Cavia porcellus | 17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH | i.e. cortisone | ? |
Synonyms | Comment | Organism |
---|---|---|
11beta-OHSD | - |
Cavia porcellus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Cavia porcellus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.059 | - |
IC50: 0.059 mM, competitive | Cavia porcellus | Furosemide | |
0.254 | - |
IC50: 0.254 mM | Cavia porcellus | 3beta-hydroxy-11-oxo-18beta-olean-12-en-30-oic-acid | |
0.336 | - |
IC50: 0.336 mM | Cavia porcellus | naringenin | |
0.452 | - |
IC50: 0.452 mM | Cavia porcellus | Ethacrynic acid | |
0.513 | - |
IC50: 0.513 mM | Cavia porcellus | chenodeoxycholic acid | |
1.358 | - |
IC50: 1.358 mM | Cavia porcellus | Phenylbutazone | |
1.395 | - |
IC50: 1.395 mM | Cavia porcellus | sistosterol | |
1.968 | - |
IC50: 1.968 mM | Cavia porcellus | stigmasterol | |
2.373 | - |
IC50: 2.373 mM | Cavia porcellus | naringin | |
3.529 | - |
IC50: 3.529 mM | Cavia porcellus | cholic acid |