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Literature summary for 1.1.1.B40 extracted from

  • Lakshim, V.; Nath, N.; Muneyyirci-Delale, O.
    Characterization of 11beta-hydroxysteroid dehydrogenase of human placenta: Evidence for the existence of two species of 11beta-hydroxysteroid dehydrogenases (1993), J. Steroid Biochem. Mol. Biol., 45, 391-397.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000084
-
11beta,21-dihydroxypregn-4-en-3,20-dione temperature not specified in the publication, pH 5.5-6 Homo sapiens
0.00089
-
17,21-dihydroxy-pregn-4-ene-3,11,20-trione i.e. cortisone, temperature not specified in the publication, pH 5.5-6 Homo sapiens
0.0014
-
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione i.e. cortisol, temperature not specified in the publication, pH 5.5-6 Homo sapiens
0.0022
-
21-hydroxy-pregn-4-en-3,11,20-trione temperature not specified in the publication, pH 5.5-6 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+ Homo sapiens i.e. cortisol 17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH i.e. cortisone r
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+ Homo sapiens i.e. corticosterone 21-hydroxy-pregn-4-en-3,11,20-trione + NADH
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta two forms present, one NAD-specific the other NADP+-dependent Homo sapiens
-

Storage Stability

Storage Stability Organism
-20°C, cytosol depleted fraction, 10 mM phosphate buffer, 0.25 M sucrose, stable for 2 days Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+ i.e. cortisol Homo sapiens 17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADH i.e. cortisone r
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+ i.e. corticosterone Homo sapiens 21-hydroxy-pregn-4-en-3,11,20-trione + NADH
-
r

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
4
-
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5 6 oxidase activity Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
5 10 11-dehydrogenase activity, broad range of pH optimum Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADH
-
Homo sapiens