Literature summary for 1.1.1.B40 extracted from

Zhao, B.; Lian, Q.; Chu, Y.; Hardy, D.O.; Li, X.K.; Ge, R.S.
The inhibition of human and rat 11beta-hydroxysteroid dehydrogenase 2 by perfluoroalkylated substances (2011), J. Steroid Biochem. Mol. Biol., 125, 143-147.

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Inhibitors

Inhibitors	Comment	Organism	Structure
perfluorooctane sulfonate	competitive	Homo sapiens
perfluorooctane sulfonate	isoform 11beta-HSD2, competitive	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P80365	isoform 11beta-HSD2	-
Rattus norvegicus	-	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000048	-	pH 7.2, 37°C	Homo sapiens	perfluorooctane sulfonate
0.000293	-	pH 7.2, 37°C	Rattus norvegicus	perfluorooctane sulfonate

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Release 2023.1 (January 2023)