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Literature summary for 1.1.1.B40 extracted from

  • Huebner, H.; Heussner, K.; Ruebner, M.; Schmid, M.; Nadal, J.; Woelfle, J.; Hartner, A.; Menendez-Castro, C.; Rauh, M.; Beckmann, M.W.; Kehl, S.; Fahlbusch, F.B.
    Influence of labor on direct and indirect determinants of placental 11beta-hydroxysteroid dehydrogenase activity (2021), Arch. Gynecol. Obstet., 303, 401-408 .
    View publication on PubMed
Search for more literature for 1.1.1.B40

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
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 Homo sapiens
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-

Organism

Organism UniProt Comment Textmining
Homo sapiens P80365
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-

Source Tissue

Source Tissue Comment Organism Textmining
placenta
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 Homo sapiens
-

Synonyms

Synonyms Comment Organism
11beta-HSD2/HSD11B2
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 Homo sapiens
11beta-hydroxysteroid dehydrogenase type 2
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 Homo sapiens

General Information

General Information Comment Organism
physiological function the action of cortisol on the human feto-placental unit is regulated by 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2/HSD11B2) that converts cortisol into inactive cortisone. The mRNA expression of HSD11B2 correlates with indirect and direct cortisol turnover rates in C-section placentas only. In contrast to C-sections, corticotropin-releasing hormone, cortisol and cortisone levels are significantly increased in placental samples following spontaneous birth Homo sapiens