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Literature summary for 1.1.3.9 extracted from

  • Namdjou, D.; Sauerzapfe, B.; Schmiedel, J.; Draeger, G.; Bernatchez, S.; Wakarchuk, W.W.; Elling, L.
    Combination of UDP-Glc(NAc) 4'-epimerase and galactose oxidase in a one-pot synthesis of biotinylated nucleotide sugars (2007), Adv. Synth. Catal., 349, 314-318.
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Application

Application Comment Organism
synthesis combination of UDP-Glc(NAc) 4'-epimerase and galactose oxidase in a one-pot synthesis of biotinylated nucleotide sugars. The enzymatic epimerization of uridine 5’-diphospho-alpha-D-glucose and uridine 5’-diphospho-N-acetyl-alpha-D-glucosamine and the subsequent oxidation of uridine 5’-diphospho-alpha-D-galactose and uridine 5’-diphospho-N-acetyl-alpha-D-galactosamine are combined with chemical biotinylation with biotin-epsilon-amidocaproylhydrazide in a one-pot synthesis. A mixture (1.0:1.4) of the biotinylated nucleotide sugars uridine 5’-diphospho-6-biotin-epsilon-amidocaproylhydrazino-alpha-D-galactose and uridine 5’-diphospho-6-biotin-epsilon-amidocaproylhydrazino-alpha-D-glucose, is produced in a reaction started with uridine 5’-diphospho-alpha-D-glucose. One product, uridine 5’-diphospho-6-biotin-epsilon-amidocaproylhydrazino-N-acetyl-alpha-D-galactosamine is formed when the reaction is initiated with uridine 5’-diphospho-N-acetyl-alpha-D-glucosamine Hypomyces rosellus

Organism

Organism UniProt Comment Textmining
Hypomyces rosellus
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