BRENDA - Enzyme Database show
show all sequences of 1.1.9.1

Three distinct quinoprotein alcohol dehydrogenases are expressed when Pseudomonas putida is grown on different alcohols

Toyama, H.; Fujii, A.; Matsushita, K.; Shinagawa, E.; Ameyama, M.; Adachi, O.; J. Bacteriol. 177, 2442-2450 (1995)

Data extracted from this reference:

KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.105
-
1-butanol
isoform ADH IIB, pH 8.0
Pseudomonas putida
0.15
-
1-butanol
isoform ADH IIG, pH 8.0
Pseudomonas putida
0.226
-
1,2-propanediol
isoform ADH IIG, pH 8.0
Pseudomonas putida
2.4
-
glycerol
isoform ADH IIG, pH 8.0
Pseudomonas putida
3
3.2
ethanol
isoform ADH IIG, pH 8.0
Pseudomonas putida
5.61
-
ethanol
isoform ADH IIB, pH 8.0
Pseudomonas putida
10.2
-
1,2-propanediol
isoform ADH IIB, pH 8.0
Pseudomonas putida
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
69000
-
ADH IIB, 1 * 69000, SDS-PAGE. ADH IIG, 1 * 72000, SDS-PAGE
Pseudomonas putida
72000
-
ADH IIB, 1 * 69000, SDS-PAGE. ADH IIG, 1 * 72000, SDS-PAGE
Pseudomonas putida
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Pseudomonas putida
-
-
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
14
-
isoform ADH IIG, pH 9.0
Pseudomonas putida
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1,2-butanediol + ferricyanide
ADH IIB, 84% of the activity with 1-butanol. ADH IIG, 86% of the activity with 1,2-propanediol
687362
Pseudomonas putida
2-hydroxybutanal + ferrocyanide
-
-
-
?
1,2-ethanediol + ferricyanide
ADH IIB, 0% of the activity with 1-butanol. ADH IIG, 71% of the activity with 1,2-propanediol
687362
Pseudomonas putida
hydroxyacetaldehyde + ferrocyanide
-
-
-
?
1,2-propanediol + ferricyanide
ADH IIB, 43% of the activity with 1-butanol. ADH IIG, maximum activity
687362
Pseudomonas putida
2-hydroxypropanal + ferrocyanide
-
-
-
?
1,3-butanediol + ferricyanide
ADH IIB, 105% of the activity with 1-butanol. ADH IIG, 75% of the activity with 1,2-propanediol
687362
Pseudomonas putida
3-hydroxybutanal + ferrocyanide
-
-
-
?
1,3-propandione + ferricyanide
ADH IIB, 61% of the activity with 1-butanol. ADH IIG, 42% of the activity with 1,2-propanediol
687362
Pseudomonas putida
3-hydroxypropanal + ferrocyanide
-
-
-
?
1,4-butanediol + ferricyanide
ADH IIB, 110% of the activity with 1-butanol. ADH IIG, 75% of the activity with 1,2-propanediol
687362
Pseudomonas putida
4-hydroxybutanal + ferrocyanide
-
-
-
?
1-butanol + ferricyanide
ADH IIG, 42% of the activity with 1,2-propanediol
687362
Pseudomonas putida
butanal + ferrocyanide
-
-
-
?
1-heptanol + ferricyanide
ADH IIB, 99% of the activity with 1-butanol. ADH IIG, 39% of the activity with 1,2-propanediol
687362
Pseudomonas putida
heptanal + ferrocyanide
-
-
-
?
1-hexanol + ferricyanide
ADH IIB, 70% of the activity with 1-butanol. ADH IIG, 46% of the activity with 1,2-propanediol
687362
Pseudomonas putida
hexanal + ferrocyanide
-
-
-
?
1-octanol + ferricyanide
ADH IIB, 44% of the activity with 1-butanol. ADH IIG, 24% of the activity with 1,2-propanediol
687362
Pseudomonas putida
octanal + ferrocyanide
-
-
-
?
1-pentanol + ferricyanide
ADH IIB, 100% of the activity with 1-butanol. ADH IIG, 40% of the activity with 1,2-propanediol
687362
Pseudomonas putida
pentanal + ferrocyanide
-
-
-
?
1-propanol + ferricyanide
ADH IIB, 70% of the activity with 1-butanol. ADH IIG, 41% of the activity with 1,2-propanediol
687362
Pseudomonas putida
propanal + ferrocyanide
-
-
-
?
2,3-butanediol + ferricyanide
ADH IIB, 12% of the activity with 1-butanol. ADH IIG, 71% of the activity with 1,2-propanediol
687362
Pseudomonas putida
3-hydroxybutan-2-one + ferrocyanide
-
-
-
?
2,4-pentanediol + ferricyanide
ADH IIB, 45% of the activity with 1-butanol. ADH IIG, 0% of the activity with 1,2-propanediol
687362
Pseudomonas putida
4-hydroxypentan-2-one + ferrocyanide
-
-
-
?
2-butanol + ferricyanide
ADH IIB, 90% of the activity with 1-butanol. ADH IIG, 15% of the activity with 1,2-propanediol
687362
Pseudomonas putida
butanone + ferrocyanide
-
-
-
?
2-hexanol + ferricyanide
ADH IIB, 99% of the activity with 1-butanol. ADH IIG, 33% of the activity with 1,2-propanediol
687362
Pseudomonas putida
hexan-2-one + ferrocyanide
-
-
-
?
2-pentanol + ferricyanide
ADH IIB, 120% of the activity with 1-butanol. ADH IIG, 19% of the activity with 1,2-propanediol
687362
Pseudomonas putida
pentan-2-one + ferrocyanide
-
-
-
?
2-propanol + ferricyanide
ADH IIB, 52% of the activity with 1-butanol. ADH IIG, 0% of the activity with 1,2-propanediol
687362
Pseudomonas putida
acetone + ferrocyanide
-
-
-
?
3-pentanol + ferricyanide
ADH IIB, 43% of the activity with 1-butanol. ADH IIG, 15% of the activity with 1,2-propanediol
687362
Pseudomonas putida
pentan-3-one + ferrocyanide
-
-
-
?
allyl alcohol + ferricyanide
ADH IIB, 160% of the activity with 1-butanol. ADH IIG, 46% of the activity with 1,2-propanediol
687362
Pseudomonas putida
prop-2-enal + ferrocyanide
-
-
-
?
butanal + ferrocyanide
ADH IIB, 32% of the activity with 1-butanol. ADH IIG, 13% of the activity with 1,2-propanediol
687362
Pseudomonas putida
1-butanol + ferricyanide
-
-
-
?
ethanal + ferrocyanide
ADH IIB, 78% of the activity with 1-butanol. ADH IIG, 16% of the activity with 1,2-propanediol
687362
Pseudomonas putida
ethanol + ferricyanide
-
-
-
?
ethanol + ferricyanide
ADH IIB, 78% of the activity with 1-butanol. ADH IIG, 22% of the activity with 1,2-propanediol
687362
Pseudomonas putida
ethanal + ferrocyanide
-
-
-
?
glycerol + ferrocyanide
ADH IIB, 0% of the activity with 1-butanol. ADH IIG, 63% of the activity with 1,2-propanediol
687362
Pseudomonas putida
2,3-dihydroxypropanal + ferricyanide
-
-
-
?
iso-amyl alcohol + ferricyanide
ADH IIB, 100% of the activity with 1-butanol. ADH IIG, 93% of the activity with 1,2-propanediol
687362
Pseudomonas putida
3-methylbutanol + ferrocyanide
-
-
-
?
propanal + ferrocyanide
ADH IIB, 125% of the activity with 1-butanol. ADH IIG, 58% of the activity with 1,2-propanediol
687362
Pseudomonas putida
1-propanol + ferricyanide
-
-
-
?
Subunits
Subunits
Commentary
Organism
monomer
ADH IIB, 1 * 69000, SDS-PAGE. ADH IIG, 1 * 72000, SDS-PAGE
Pseudomonas putida
Cofactor
Cofactor
Commentary
Organism
Structure
heme c
both isoforms ADH IIB and ADH IIG
Pseudomonas putida
pyrroloquinoline quinone
both isoforms ADH IIB and ADH IIG
Pseudomonas putida
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
heme c
both isoforms ADH IIB and ADH IIG
Pseudomonas putida
pyrroloquinoline quinone
both isoforms ADH IIB and ADH IIG
Pseudomonas putida
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.105
-
1-butanol
isoform ADH IIB, pH 8.0
Pseudomonas putida
0.15
-
1-butanol
isoform ADH IIG, pH 8.0
Pseudomonas putida
0.226
-
1,2-propanediol
isoform ADH IIG, pH 8.0
Pseudomonas putida
2.4
-
glycerol
isoform ADH IIG, pH 8.0
Pseudomonas putida
3
3.2
ethanol
isoform ADH IIG, pH 8.0
Pseudomonas putida
5.61
-
ethanol
isoform ADH IIB, pH 8.0
Pseudomonas putida
10.2
-
1,2-propanediol
isoform ADH IIB, pH 8.0
Pseudomonas putida
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
69000
-
ADH IIB, 1 * 69000, SDS-PAGE. ADH IIG, 1 * 72000, SDS-PAGE
Pseudomonas putida
72000
-
ADH IIB, 1 * 69000, SDS-PAGE. ADH IIG, 1 * 72000, SDS-PAGE
Pseudomonas putida
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
14
-
isoform ADH IIG, pH 9.0
Pseudomonas putida
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1,2-butanediol + ferricyanide
ADH IIB, 84% of the activity with 1-butanol. ADH IIG, 86% of the activity with 1,2-propanediol
687362
Pseudomonas putida
2-hydroxybutanal + ferrocyanide
-
-
-
?
1,2-ethanediol + ferricyanide
ADH IIB, 0% of the activity with 1-butanol. ADH IIG, 71% of the activity with 1,2-propanediol
687362
Pseudomonas putida
hydroxyacetaldehyde + ferrocyanide
-
-
-
?
1,2-propanediol + ferricyanide
ADH IIB, 43% of the activity with 1-butanol. ADH IIG, maximum activity
687362
Pseudomonas putida
2-hydroxypropanal + ferrocyanide
-
-
-
?
1,3-butanediol + ferricyanide
ADH IIB, 105% of the activity with 1-butanol. ADH IIG, 75% of the activity with 1,2-propanediol
687362
Pseudomonas putida
3-hydroxybutanal + ferrocyanide
-
-
-
?
1,3-propandione + ferricyanide
ADH IIB, 61% of the activity with 1-butanol. ADH IIG, 42% of the activity with 1,2-propanediol
687362
Pseudomonas putida
3-hydroxypropanal + ferrocyanide
-
-
-
?
1,4-butanediol + ferricyanide
ADH IIB, 110% of the activity with 1-butanol. ADH IIG, 75% of the activity with 1,2-propanediol
687362
Pseudomonas putida
4-hydroxybutanal + ferrocyanide
-
-
-
?
1-butanol + ferricyanide
ADH IIG, 42% of the activity with 1,2-propanediol
687362
Pseudomonas putida
butanal + ferrocyanide
-
-
-
?
1-heptanol + ferricyanide
ADH IIB, 99% of the activity with 1-butanol. ADH IIG, 39% of the activity with 1,2-propanediol
687362
Pseudomonas putida
heptanal + ferrocyanide
-
-
-
?
1-hexanol + ferricyanide
ADH IIB, 70% of the activity with 1-butanol. ADH IIG, 46% of the activity with 1,2-propanediol
687362
Pseudomonas putida
hexanal + ferrocyanide
-
-
-
?
1-octanol + ferricyanide
ADH IIB, 44% of the activity with 1-butanol. ADH IIG, 24% of the activity with 1,2-propanediol
687362
Pseudomonas putida
octanal + ferrocyanide
-
-
-
?
1-pentanol + ferricyanide
ADH IIB, 100% of the activity with 1-butanol. ADH IIG, 40% of the activity with 1,2-propanediol
687362
Pseudomonas putida
pentanal + ferrocyanide
-
-
-
?
1-propanol + ferricyanide
ADH IIB, 70% of the activity with 1-butanol. ADH IIG, 41% of the activity with 1,2-propanediol
687362
Pseudomonas putida
propanal + ferrocyanide
-
-
-
?
2,3-butanediol + ferricyanide
ADH IIB, 12% of the activity with 1-butanol. ADH IIG, 71% of the activity with 1,2-propanediol
687362
Pseudomonas putida
3-hydroxybutan-2-one + ferrocyanide
-
-
-
?
2,4-pentanediol + ferricyanide
ADH IIB, 45% of the activity with 1-butanol. ADH IIG, 0% of the activity with 1,2-propanediol
687362
Pseudomonas putida
4-hydroxypentan-2-one + ferrocyanide
-
-
-
?
2-butanol + ferricyanide
ADH IIB, 90% of the activity with 1-butanol. ADH IIG, 15% of the activity with 1,2-propanediol
687362
Pseudomonas putida
butanone + ferrocyanide
-
-
-
?
2-hexanol + ferricyanide
ADH IIB, 99% of the activity with 1-butanol. ADH IIG, 33% of the activity with 1,2-propanediol
687362
Pseudomonas putida
hexan-2-one + ferrocyanide
-
-
-
?
2-pentanol + ferricyanide
ADH IIB, 120% of the activity with 1-butanol. ADH IIG, 19% of the activity with 1,2-propanediol
687362
Pseudomonas putida
pentan-2-one + ferrocyanide
-
-
-
?
2-propanol + ferricyanide
ADH IIB, 52% of the activity with 1-butanol. ADH IIG, 0% of the activity with 1,2-propanediol
687362
Pseudomonas putida
acetone + ferrocyanide
-
-
-
?
3-pentanol + ferricyanide
ADH IIB, 43% of the activity with 1-butanol. ADH IIG, 15% of the activity with 1,2-propanediol
687362
Pseudomonas putida
pentan-3-one + ferrocyanide
-
-
-
?
allyl alcohol + ferricyanide
ADH IIB, 160% of the activity with 1-butanol. ADH IIG, 46% of the activity with 1,2-propanediol
687362
Pseudomonas putida
prop-2-enal + ferrocyanide
-
-
-
?
butanal + ferrocyanide
ADH IIB, 32% of the activity with 1-butanol. ADH IIG, 13% of the activity with 1,2-propanediol
687362
Pseudomonas putida
1-butanol + ferricyanide
-
-
-
?
ethanal + ferrocyanide
ADH IIB, 78% of the activity with 1-butanol. ADH IIG, 16% of the activity with 1,2-propanediol
687362
Pseudomonas putida
ethanol + ferricyanide
-
-
-
?
ethanol + ferricyanide
ADH IIB, 78% of the activity with 1-butanol. ADH IIG, 22% of the activity with 1,2-propanediol
687362
Pseudomonas putida
ethanal + ferrocyanide
-
-
-
?
glycerol + ferrocyanide
ADH IIB, 0% of the activity with 1-butanol. ADH IIG, 63% of the activity with 1,2-propanediol
687362
Pseudomonas putida
2,3-dihydroxypropanal + ferricyanide
-
-
-
?
iso-amyl alcohol + ferricyanide
ADH IIB, 100% of the activity with 1-butanol. ADH IIG, 93% of the activity with 1,2-propanediol
687362
Pseudomonas putida
3-methylbutanol + ferrocyanide
-
-
-
?
propanal + ferrocyanide
ADH IIB, 125% of the activity with 1-butanol. ADH IIG, 58% of the activity with 1,2-propanediol
687362
Pseudomonas putida
1-propanol + ferricyanide
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
monomer
ADH IIB, 1 * 69000, SDS-PAGE. ADH IIG, 1 * 72000, SDS-PAGE
Pseudomonas putida
General Information
General Information
Commentary
Organism
metabolism
ADH IIB is formed in the cells grown on alcohols of medium chain length and also on 1,3-butanediol. Induction of ADH IIG is restricted to 1,2-propanediol or glycerol, of which the former alcohol is more effective
Pseudomonas putida
General Information (protein specific)
General Information
Commentary
Organism
metabolism
ADH IIB is formed in the cells grown on alcohols of medium chain length and also on 1,3-butanediol. Induction of ADH IIG is restricted to 1,2-propanediol or glycerol, of which the former alcohol is more effective
Pseudomonas putida
Other publictions for EC 1.1.9.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
654868
Jongejan
Deuterium isotope effect on en ...
Comamonas testosteroni
Biochim. Biophys. Acta
1647
297-302
2003
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1
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656080
Oubrie
Crystal structure of quinohemo ...
Comamonas testosteroni
J. Biol. Chem.
277
3727-3732
2002
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1
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678768
Toyama
Azurin involved in alcohol oxi ...
Pseudomonas putida
Biosci. Biotechnol. Biochem.
65
1617-1626
2001
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-
1
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2
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1
-
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1
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1
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1
1
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1
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701480
Oubrie
Crystallization of quinohemopr ...
Comamonas testosteroni
Acta Crystallogr. Sect. D
D57
1732-1734
2001
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1
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1
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1
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1
1
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-
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701774
Somers
-
Enantioselective oxidation of ...
Comamonas testosteroni
Appl. Biochem. Biotechnol.
75
151-161
1999
-
1
-
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-
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50
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1
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35
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1
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50
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35
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705187
Stigter
-
Enantioselective oxidation of ...
Comamonas testosteroni
J. Mol. Catal. B
2
291-297
1997
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21
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1
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22
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21
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22
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-
-
389956
De Jong
Characterization of the intera ...
Comamonas testosteroni
Biochemistry
34
9451-9458
1995
-
-
-
-
-
-
-
-
-
-
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-
1
-
-
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-
-
-
-
-
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-
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-
-
-
-
-
-
2
-
-
-
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-
-
2
-
-
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
389960
De Jong
Quinohemoprotein ethanol dehyd ...
Comamonas testosteroni
Eur. J. Biochem.
230
899-905
1995
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-
-
-
-
-
-
-
-
1
2
-
-
1
-
-
1
-
-
-
1
-
1
1
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-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
2
-
-
-
-
1
-
-
1
-
1
1
-
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-
-
-
-
-
-
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-
687362
Toyama
Three distinct quinoprotein al ...
Pseudomonas putida
J. Bacteriol.
177
2442-2450
1995
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-
-
-
-
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7
-
-
2
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1
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1
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26
1
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2
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-
2
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7
-
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2
-
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-
1
-
26
1
-
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1
1
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-
703526
Geerlof
Description of the kinetic mec ...
Comamonas testosteroni
Eur. J. Biochem.
226
537-546
1994
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-
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6
-
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1
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7
-
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7
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6
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7
-
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7
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6
6
389953
Groen
Quinohaemoprotein alcohol dehy ...
Comamonas testosteroni
Biochem. J.
234
611-615
1986
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12
-
1
2
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1
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2
15
1
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-
1
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-
2
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-
-
2
-
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-
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-
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12
-
1
2
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2
15
1
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-
1
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