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Literature summary for 1.1.99.1 extracted from

  • Johnson, A.R.; Craciunescu, C.N.; Guo, Z.; Teng, Y.W.; Thresher, R.J.; Blusztajn, J.K.; Zeisel, S.H.
    Deletion of murine choline dehydrogenase results in diminished sperm motility (2010), FASEB J., 24, 2752-2761.
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial membrane
-
 Mus musculus 31966
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Mus musculus
-
kidney highest activity Mus musculus
-
liver highest activity Mus musculus
-
additional information almost no activity is detected in brain and skeletal muscle Mus musculus
-
testis highest activity Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
choline + acceptor
-
 Mus musculus betaine aldehyde + reduced acceptor
-
 ?

Synonyms

Synonyms Comment Organism
CHDH
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus liver samples from Chdh-deficient mice have 37% of the CHDH activity measured in wild type samples down

General Information

General Information Comment Organism
malfunction deletion of choline dehydrogenase results in diminished sperm motility with abnormal mitochondrial morphology, but does not affect fetal viability or alter growth or liver, kidney, or muscle function. Loss of choline dehydrogenase activity results in decreased testicular betaine and increased choline and phosphocholine concentrations. Mitochondrial changes are also detected in liver, kidney, heart, and testis tissues. Chdh-deficient mice have increased plasma total homocysteine Mus musculus