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Literature summary for 1.1.99.2 extracted from

  • Hariharan, V.A.; Denton, T.T.; Paraszcszak, S.; McEvoy, K.; Jeitner, T.M.; Krasnikov, B.F.; Cooper, A.J.
    The enzymology of 2-hydroxyglutarate, 2-hydroxyglutaramate and 2-hydroxysuccinamate and their relationship to oncometabolites (2017), Biology, 6, E24 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-2-hydroxyglutarate + FAD Homo sapiens
-
2-oxoglutarate + FADH2
-
ir
L-2-hydroxyglutarate + NAD+ Homo sapiens
-
2-oxoglutarate + NADH + H+
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-2-hydroxyglutarate + FAD
-
Homo sapiens 2-oxoglutarate + FADH2
-
ir
L-2-hydroxyglutarate + NAD+
-
Homo sapiens 2-oxoglutarate + NADH + H+
-
r

Synonyms

Synonyms Comment Organism
L-2-HG dehydrogenase
-
Homo sapiens

General Information

General Information Comment Organism
malfunction L-2-hydroxyglutaric aciduria is a rare inborn error of metabolism in the enzyme is defective Homo sapiens