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show all sequences of 1.1.99.24

An overview of gamma-hydroxybutyrate catabolism: the role of the cytosolic NADP+-dependent oxidoreductase EC 1.1.1.19 and of a mitochondrial hydroxyacid-oxoacid transhydrogenase in the initial, rate-limiting step in this pathway

Kaufman, E.E.; Nelson, T.; Neurochem. Res. 16, 965-974 (1991)

Data extracted from this reference:

KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0046
-
Succinic semialdehyde
-
Rattus norvegicus
0.018
-
2-oxoglutarate
-
Rattus norvegicus
0.3
-
4-hydroxybutyrate
-
Rattus norvegicus
0.42
-
D-2-hydroxyglutarate
-
Rattus norvegicus
3
-
L-3-hydroxybutyrate
-
Rattus norvegicus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Rattus norvegicus
-
-
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
0.0166 micromol/min*g brain tissue; 0.172 micromol/min*g kidney tissue
Rattus norvegicus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4-hydroxybutyrate + 2-oxoglutarate
-
286147
Rattus norvegicus
succinic semialdehyde + 2-hydroxyglutarate
-
286147
Rattus norvegicus
r
D-2-hydroxyglutarate + succinic semialdehyde
-
286147
Rattus norvegicus
2-oxoglutarate + 4-hydroxybutyrate
-
286147
Rattus norvegicus
?
L-3-hydroxybutyrate + 2-oxoglutarate
-
286147
Rattus norvegicus
acetoacetate + 2-oxoglutarate
-
286147
Rattus norvegicus
?
L-3-hydroxybutyrate + succinic semialdehyde
-
286147
Rattus norvegicus
acetoacetate + 4-hydroxybutyrate
-
286147
Rattus norvegicus
?
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0046
-
Succinic semialdehyde
-
Rattus norvegicus
0.018
-
2-oxoglutarate
-
Rattus norvegicus
0.3
-
4-hydroxybutyrate
-
Rattus norvegicus
0.42
-
D-2-hydroxyglutarate
-
Rattus norvegicus
3
-
L-3-hydroxybutyrate
-
Rattus norvegicus
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
0.0166 micromol/min*g brain tissue; 0.172 micromol/min*g kidney tissue
Rattus norvegicus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4-hydroxybutyrate + 2-oxoglutarate
-
286147
Rattus norvegicus
succinic semialdehyde + 2-hydroxyglutarate
-
286147
Rattus norvegicus
r
D-2-hydroxyglutarate + succinic semialdehyde
-
286147
Rattus norvegicus
2-oxoglutarate + 4-hydroxybutyrate
-
286147
Rattus norvegicus
?
L-3-hydroxybutyrate + 2-oxoglutarate
-
286147
Rattus norvegicus
acetoacetate + 2-oxoglutarate
-
286147
Rattus norvegicus
?
L-3-hydroxybutyrate + succinic semialdehyde
-
286147
Rattus norvegicus
acetoacetate + 4-hydroxybutyrate
-
286147
Rattus norvegicus
?
Other publictions for EC 1.1.99.24
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
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2
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1
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1
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1
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1
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1
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664967
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580
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1
-
1
-
-
-
3
10
1
1
3
4
-
6
-
-
1
-
-
9
1
-
6
1
2
-
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-
2
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2
2
-
2
1
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1
2
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2
3
2
10
1
1
3
4
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1
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9
1
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6
1
2
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2
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675230
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2
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3
1
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3
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1
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1
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1
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1
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2
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3
1
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3
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1
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-
1
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-
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286147
Kaufman
An overview of gamma-hydroxybu ...
Rattus norvegicus
Neurochem. Res.
16
965-974
1991
-
-
-
-
-
-
-
5
-
-
-
-
-
1
-
-
-
-
-
-
1
-
4
-
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5
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1
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4
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287797
Kaufman
Isolation and characterization ...
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
J. Biol. Chem.
263
16872-16879
1988
-
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1
1
5
2
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162
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1
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4
1
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10
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1
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1
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1
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1
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1
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1
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5
2
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1
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4
1
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10
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1
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1
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