BRENDA - Enzyme Database show
show all sequences of 1.1.99.24

Enzymes involved in the metabolism of gamma-hydroxybutyrate in SH-SY5Y cells: identification of an iron-dependent alcohol dehydrogenase ADHFe1

Lyon, R.C.; Johnston, S.M.; Panopoulos, A.; Alzeer, S.; McGarvie, G.; Ellis, E.M.; Chem. Biol. Interact. 178, 283-287 (2009)

Data extracted from this reference:

Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
Q8IWW8
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
SH-SY5Y cell
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4-hydroxybutanoic acid + 2-oxoglutarate
-
697277
Homo sapiens
succinic semialdehyde + D-2-hydroxyglutarate
-
-
-
?
Cofactor
Cofactor
Commentary
Organism
Structure
NAD(P)+
2-oxoglutarate serves as an intermediate acceptor to generate NAD(P)H
Homo sapiens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD(P)+
2-oxoglutarate serves as an intermediate acceptor to generate NAD(P)H
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
SH-SY5Y cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4-hydroxybutanoic acid + 2-oxoglutarate
-
697277
Homo sapiens
succinic semialdehyde + D-2-hydroxyglutarate
-
-
-
?
Other publictions for EC 1.1.99.24
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
741433
Yang
RNA interference-mediated knoc ...
Bemisia tabaci
Sci. Rep.
7
41201
2017
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
1
-
1
1
-
-
-
741263
Gaona-Lopez
Diversity and evolutionary ana ...
Acanthamoeba castellanii, Acanthamoeba castellanii NEFF, Acytostelium subglobosum, Acytostelium subglobosum LB1, Aphanomyces astaci, Aphanomyces astaci APO3, Aphanomyces invadans, Aphanomyces invadans NJM9701, Capsaspora owczarzaki, Capsaspora owczarzaki ATCC 30864, Dictyostelium discoideum, Dictyostelium purpureum, Heterostelium pallidum, Phaeodactylum tricornutum, Phaeodactylum tricornutum CCAP 1055/1, Reticulomyxa filosa, Saprolegnia diclina, Saprolegnia diclina VS20, Saprolegnia parasitica, Saprolegnia parasitica CBS223.65, Thalassiosira oceanica, Thecamonas trahens, Thecamonas trahens ATCC 50062, Tieghemostelium lacteum
PLoS ONE
11
e0166851
2016
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-
-
-
-
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-
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14
-
34
-
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14
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14
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-
-
-
-
-
14
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697277
Lyon
Enzymes involved in the metabo ...
Homo sapiens
Chem. Biol. Interact.
178
283-287
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
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-
-
1
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1
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1
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1
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1
-
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1
-
-
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-
-
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-
-
-
-
-
-
-
-
-
664967
Kardon
Identification of the gene enc ...
Homo sapiens, Mus musculus, Rattus norvegicus
FEBS Lett.
580
2347-2350
2006
1
-
1
-
-
-
3
10
1
1
3
4
-
6
-
-
1
-
-
9
1
-
6
1
2
-
-
-
2
-
-
2
2
-
2
1
-
1
2
-
-
-
2
3
2
10
1
1
3
4
-
-
-
1
-
9
1
-
6
1
2
-
-
-
2
-
-
-
-
-
-
-
-
-
675230
Struys
Kinetic characterization of hu ...
Homo sapiens
J. Inherit. Metab. Dis.
28
921-930
2005
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
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-
-
3
1
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3
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1
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1
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1
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-
1
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-
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-
-
2
-
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3
1
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3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
286147
Kaufman
An overview of gamma-hydroxybu ...
Rattus norvegicus
Neurochem. Res.
16
965-974
1991
-
-
-
-
-
-
-
5
-
-
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1
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1
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4
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-
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5
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1
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4
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287797
Kaufman
Isolation and characterization ...
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
J. Biol. Chem.
263
16872-16879
1988
-
-
-
-
-
1
1
5
2
-
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-
-
162
-
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1
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4
1
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10
-
1
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1
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1
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-
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-
-
1
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1
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1
-
5
2
-
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-
1
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4
1
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10
-
1
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1
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