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Literature summary for extracted from

  • Goldman, P.J.; Grove, T.L.; Booker, S.J.; Drennan, C.L.
    X-ray analysis of butirosin biosynthetic enzyme BtrN redefines structural motifs for AdoMet radical chemistry (2013), Proc. Natl. Acad. Sci. USA, 110, 15949-15954.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with AdoMet and substrate, to 1.56 A resolution. Structure displays a modification to the core AdoMet radical fold, instead of the canonical (beta/alpha)6 architecture, BtrN displays a (beta5/alpha4) motif. An auxiliary [4Fe-4S] cluster in BtrN, thought to bind substrate, is instead implicated in substrate-radical oxidation Niallia circulans


Organism UniProt Comment Textmining
Niallia circulans Q8G907


Synonyms Comment Organism
Niallia circulans
DOIA dehydrogenase
Niallia circulans


Cofactor Comment Organism Structure
[4Fe-4S]-center cluster is implicated in substrate-radical oxidation Niallia circulans