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Literature summary for 1.1.99.39 extracted from

  • Berger, R.S.; Ellmann, L.; Reinders, J.; Kreutz, M.; Stempfl, T.; Oefner, P.J.; Dettmer, K.
    Degradation of D-2-hydroxyglutarate in the presence of isocitrate dehydrogenase mutations (2019), Sci. Rep., 9, 7436 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.99.39

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N465
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HT-1080 cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-2-hydroxyglutarate + phenazine methosulfate
-
 Homo sapiens 2-oxoglutarate + reduced phenazine methosulfate
-
 ?

Synonyms

Synonyms Comment Organism
D-2-hydroxyglutarate dehydrogenase
-
 Homo sapiens
D2HDH
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens expression of the enzyme is upregulated in the presence of high endogenous concentrations of (S)-2-hydroxyglutarate up