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Literature summary for extracted from

  • Edge, A.; Qu, Y.; Easson, M.L.A.E.; Thamm, A.M.K.; Kim, K.H.; De Luca, V.
    A tabersonine 3-reductase Catharanthus roseus mutant accumulates vindoline pathway intermediates (2018), Planta, 247, 155-169 .
    View publication on PubMed


Cloned (Comment) Organism
expressed in Escherichia coli BL21-(DE3) cells Catharanthus roseus

Protein Variants

Protein Variants Comment Organism
H189Y the mutation diminishes the activity of the enzyme by 95% Catharanthus roseus
T305T inactive Catharanthus roseus


Organism UniProt Comment Textmining
Catharanthus roseus A0A161CAI1

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography Catharanthus roseus

Source Tissue

Source Tissue Comment Organism Textmining
Catharanthus roseus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
16-methoxytabersonine + NADPH + H+
Catharanthus roseus 3-hydroxy-16-methoxy-2,3-dihydrotabersonine
tabersonine + NADPH + H+
Catharanthus roseus 2,3-dihydro-3-hydroxytabersonine + NADP+


Synonyms Comment Organism
Catharanthus roseus
tabersonine 3-reductas
Catharanthus roseus