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Literature summary for 1.10.3.1 extracted from

  • Cho, S.J.; Roh, J.S.; Sun, W.S.; Kim, S.H.; Park, K.D.
    N-Benzylbenzamides: A new class of potent tyrosinase inhibitors (2006), Bioorg. Med. Chem. Lett., 16, 2682-2684.
    View publication on PubMed
Search for more literature for 1.10.3.1

Inhibitors

Inhibitors Comment Organism Structure
2,4-dihydroxy-N-(3,4,5-trihydroxybenzyl)benzamide IC50: 0.550 mM Agaricus bisporus
2,4-dihydroxy-N-(4-hydroxybenzyl)benzamide IC50: 1.820 mM Agaricus bisporus
3,4,5-trihydroxy-N-(3,4,5-trihydroxybenzyl)benzamide IC50: 0.555 mM Agaricus bisporus
3,4,5-trihydroxy-N-(4-hydroxybenzyl)benzamide IC50: 1.180 mM Agaricus bisporus
3,4-dihydroxy-N-(3,4,5-trihydroxybenzyl)benzamide IC50: 0.280 mM Agaricus bisporus
3,4-dihydroxy-N-(4-hydroxybenzyl)benzamide IC50: 2.0 mM Agaricus bisporus
3,5-dihydroxy-N-(3,4,5-trihydroxybenzyl)benzamide IC50: 0.705 mM Agaricus bisporus
3,5-dihydroxy-N-(4-hydroxybenzyl)benzamide IC50: 0.710 mM Agaricus bisporus
kojic acid IC50: 0.0163 mM Agaricus bisporus
N-(2,4-dihydroxybenzyl)-2,4-dihydroxybenzamide IC50: 0.029 mM Agaricus bisporus
N-(2,4-dihydroxybenzyl)-3,4,5-trihydroxybenzamide IC50: 0.017 mM Agaricus bisporus
N-(2,4-dihydroxybenzyl)-3,4-dihydroxybenzamide IC50: 0.011 mM Agaricus bisporus
N-(2,4-dihydroxybenzyl)-3,5-dihydroxybenzamide IC50: 0.0022 mM Agaricus bisporus
N-benzyl-2,4-dihydroxybenzamide IC50: 1.660 mM Agaricus bisporus
N-benzyl-3,4,5-trihydroxybenzamide IC50: 0.780 mM Agaricus bisporus
N-benzyl-3,4-dihydroxybenzamide IC50: 2.0 mM Agaricus bisporus
N-benzyl-3,5-dihydroxybenzamide IC50: 0.700 mM Agaricus bisporus
N-benzylamide IC50: 1.990 mM Agaricus bisporus
N-benzylbenzamide derivatives inhibitory potency, structure-activity relationships, overview Agaricus bisporus

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ copper enzyme Agaricus bisporus

Organism

Organism UniProt Comment Textmining
Agaricus bisporus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Agaricus bisporus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-DOPA + O2
-
 Agaricus bisporus ?
-
 ?
additional information the enzyme catalyzes the hydroxylation of monophenols to o-diphenols, monophenolase activity EC 1.14.18.1, and the oxidation of the o-diphenols to o-quinones, diphenolase activity EC 1.10.3.1, cross-reaction analysis, overview Agaricus bisporus ?
-
 ?

Synonyms

Synonyms Comment Organism
More cf. EC 1.14.18.1 Agaricus bisporus
tyrosinase
-
 Agaricus bisporus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0022
-
 IC50: 0.0022 mM Agaricus bisporus N-(2,4-dihydroxybenzyl)-3,5-dihydroxybenzamide
0.011
-
 IC50: 0.011 mM Agaricus bisporus N-(2,4-dihydroxybenzyl)-3,4-dihydroxybenzamide
0.0163
-
 IC50: 0.0163 mM Agaricus bisporus kojic acid
0.017
-
 IC50: 0.017 mM Agaricus bisporus N-(2,4-dihydroxybenzyl)-3,4,5-trihydroxybenzamide
0.029
-
 IC50: 0.029 mM Agaricus bisporus N-(2,4-dihydroxybenzyl)-2,4-dihydroxybenzamide
0.28
-
 IC50: 0.280 mM Agaricus bisporus 3,4-dihydroxy-N-(3,4,5-trihydroxybenzyl)benzamide
0.55
-
 IC50: 0.550 mM Agaricus bisporus 2,4-dihydroxy-N-(3,4,5-trihydroxybenzyl)benzamide
0.555
-
 IC50: 0.555 mM Agaricus bisporus 3,4,5-trihydroxy-N-(3,4,5-trihydroxybenzyl)benzamide
0.7
-
 IC50: 0.700 mM Agaricus bisporus N-benzyl-3,5-dihydroxybenzamide
0.705
-
 IC50: 0.705 mM Agaricus bisporus 3,5-dihydroxy-N-(3,4,5-trihydroxybenzyl)benzamide
0.71
-
 IC50: 0.710 mM Agaricus bisporus 3,5-dihydroxy-N-(4-hydroxybenzyl)benzamide
0.78
-
 IC50: 0.780 mM Agaricus bisporus N-benzyl-3,4,5-trihydroxybenzamide
1.18
-
 IC50: 1.180 mM Agaricus bisporus 3,4,5-trihydroxy-N-(4-hydroxybenzyl)benzamide
1.66
-
 IC50: 1.660 mM Agaricus bisporus N-benzyl-2,4-dihydroxybenzamide
1.82
-
 IC50: 1.820 mM Agaricus bisporus 2,4-dihydroxy-N-(4-hydroxybenzyl)benzamide
1.99
-
 IC50: 1.990 mM Agaricus bisporus N-benzylamide
2
-
 IC50: 2.0 mM Agaricus bisporus N-benzyl-3,4-dihydroxybenzamide
2
-
 IC50: 2.0 mM Agaricus bisporus 3,4-dihydroxy-N-(4-hydroxybenzyl)benzamide