Literature summary for 1.10.3.11 extracted from

Rodrigues, A.P.C.; Camargo, A.F.; Andjelkovic, A.; Jacobs, H.T.; Oliveira, M.T.
Developmental arrest in Drosophila melanogaster caused by mitochondrial DNA replication defects cannot be rescued by the alternative oxidase (2018), Sci. Rep., 8, 10882 .

Search for more literature for 1.10.3.11

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Ciona intestinalis	5739	-

Organism

Organism	UniProt	Comment	Textmining
Ciona intestinalis	-	-	-

Synonyms

Synonyms	Comment	Organism
alternative oxidase	-	Ciona intestinalis
AOX	-	Ciona intestinalis

General Information

General Information	Comment	Organism
additional information	developmental arrest in Drosophila melanogaster caused by mitochondrial DNA replication defects cannot be rescued by xenotopic expression of the alternative oxidase (AOX) from Ciona intestinalis. AOX does not rescue developmental lethality, nor alter the biochemical and molecular parameters associated with Twinkle and pol gamma mutations or knockdown. This restricts the potential therapeutic use of AOX to specific types of mitochondrial dysfunction	Ciona intestinalis

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)