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Literature summary for 1.10.3.4 extracted from

  • Le Roes-Hill, M.; Goodwin, C.; Burton, S.
    Phenoxazinone synthase: whats' in a name? (2009), Trends Biotechnol., 27, 248-258.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2,3-Dimercaptopropanol
-
Bauhinia monandra
2-Aminophenol inhibitory above 0.6 mM Trametes coccinea
2-Nitrophenol
-
Streptomyces griseus subsp. griseus
3-amino-4-hydroxybenzensulfonic acid
-
Streptomyces griseus subsp. griseus
3-hydroxyanthranilic acid
-
Bauhinia monandra
4-hydroxy-3-nitrobenzaldehyde
-
Streptomyces griseus subsp. griseus
4-hydroxybenzaldehyde
-
Streptomyces griseus subsp. griseus
8-hydroxyquinoline
-
Streptomyces antibioticus
Ag+
-
Bauhinia monandra
alpha,alpha'-dipyridyl
-
Streptomyces antibioticus
aniline
-
Streptomyces griseus subsp. griseus
anthranilic acid
-
Bauhinia monandra
ascorbic acid
-
Bauhinia monandra
ascorbic acid
-
Trametes coccinea
Atebrin
-
Bauhinia monandra
Atebrin
-
Tecoma stans
azide
-
Bauhinia monandra
azide
-
Streptomyces antibioticus
Co2+
-
Tecoma stans
Cu2+
-
Bauhinia monandra
Cu2+
-
Streptomyces antibioticus
CuSO4
-
Trametes coccinea
cyanide
-
Bauhinia monandra
cyanide
-
Streptomyces antibioticus
cyanide
-
Tecoma stans
cysteine
-
Bauhinia monandra
cysteine
-
Trametes coccinea
EDTA
-
Streptomyces antibioticus
Fe2+
-
Bauhinia monandra
Fe2+
-
Streptomyces antibioticus
Fe3+
-
Tecoma stans
FeSO4
-
Trametes coccinea
glutathione
-
Bauhinia monandra
glutathione
-
Trametes coccinea
Hg2+
-
Bauhinia monandra
Hg2+
-
Tecoma stans
K+
-
Streptomyces antibioticus
L-tyrosine
-
Streptomyces griseus subsp. griseus
Mg2+
-
Tecoma stans
N-ethylmaleimide
-
Bauhinia monandra
N-ethylmaleimide
-
Trametes coccinea
Na3AsO3
-
Trametes coccinea
NaBH4
-
Trametes coccinea
NH4+
-
Streptomyces antibioticus
p-chloromercuribenzoate
-
Trametes coccinea
p-hydroxymercuribenzoate
-
Bauhinia monandra
phenol
-
Streptomyces griseus subsp. griseus
Sodium diethyldithiocarbamate
-
Streptomyces antibioticus
Zn2+
-
Streptomyces antibioticus

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ GriF is a type 3 copper oxidase and contains two copper atoms Streptomyces griseus subsp. griseus
Cu2+ the enzyme is a blue multicopper oxidase Streptomyces antibioticus
Mn2+ required Trametes coccinea
Mn2+ required Tecoma stans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 2-aminophenol + 2 O2 Streptomyces antibioticus
-
isophenoxazine + 2 H2O + H2O2
-
?
2 2-aminophenol + 2 O2 Trametes coccinea
-
isophenoxazine + 2 H2O + H2O2
-
?
2 2-aminophenol + 2 O2 Tecoma stans
-
isophenoxazine + 2 H2O + H2O2
-
?
2 2-aminophenol + 2 O2 Bauhinia monandra
-
isophenoxazine + 2 H2O + H2O2
-
?
2 2-aminophenol + 2 O2 Streptomyces griseus subsp. griseus
-
isophenoxazine + 2 H2O + H2O2
-
?
2-amino-4-methylphenol + O2 Streptomyces griseus subsp. griseus
-
?
-
?
3,4-dihydroxybenzaldehyde + O2 Streptomyces griseus subsp. griseus
-
?
-
?
3-amino-4-hydroxybenzaldehyde + O2 Streptomyces griseus subsp. griseus
-
?
-
?
3-hydroxyanthranilic acid + O2 Streptomyces antibioticus
-
2-amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid + H2O
-
?
3-hydroxyanthranilic acid + O2 Streptomyces griseus subsp. griseus
-
2-amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid + H2O
-
?
3-hydroxykynurenine + O2 Streptomyces antibioticus
-
?
-
?
4-methyl-3-hydroanthranilic acid methyl ester + O2 Streptomyces antibioticus
-
?
-
?
4-methyl-3-hydroxyanthranilic acid + O2 Streptomyces antibioticus
-
?
-
?
catechol + O2 Streptomyces antibioticus
-
?
-
?
catechol + O2 Streptomyces griseus subsp. griseus
-
?
-
?
ferrocyanide + O2 Streptomyces antibioticus
-
?
-
?
L-DOPA + O2 Streptomyces antibioticus
-
?
-
?
L-DOPA + O2 Streptomyces griseus subsp. griseus
-
?
-
?
protocatechuic acid + O2 Streptomyces griseus subsp. griseus
-
?
-
?
thiophenol + O2 Streptomyces antibioticus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Bauhinia monandra
-
-
-
Streptomyces antibioticus
-
-
-
Streptomyces griseus subsp. griseus
-
-
-
Tecoma stans
-
-
-
Trametes coccinea
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 2-aminophenol + 2 O2
-
Streptomyces antibioticus isophenoxazine + 2 H2O + H2O2
-
?
2 2-aminophenol + 2 O2
-
Trametes coccinea isophenoxazine + 2 H2O + H2O2
-
?
2 2-aminophenol + 2 O2
-
Tecoma stans isophenoxazine + 2 H2O + H2O2
-
?
2 2-aminophenol + 2 O2
-
Bauhinia monandra isophenoxazine + 2 H2O + H2O2
-
?
2 2-aminophenol + 2 O2
-
Streptomyces griseus subsp. griseus isophenoxazine + 2 H2O + H2O2
-
?
2-amino-4-methylphenol + O2
-
Streptomyces griseus subsp. griseus ?
-
?
3,4-dihydroxybenzaldehyde + O2
-
Streptomyces griseus subsp. griseus ?
-
?
3-amino-4-hydroxybenzaldehyde + O2
-
Streptomyces griseus subsp. griseus ?
-
?
3-hydroxyanthranilic acid + O2
-
Streptomyces antibioticus 2-amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid + H2O
-
?
3-hydroxyanthranilic acid + O2
-
Streptomyces griseus subsp. griseus 2-amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid + H2O
-
?
3-hydroxykynurenine + O2
-
Streptomyces antibioticus ?
-
?
4-methyl-3-hydroanthranilic acid methyl ester + O2
-
Streptomyces antibioticus ?
-
?
4-methyl-3-hydroxyanthranilic acid + O2
-
Streptomyces antibioticus ?
-
?
catechol + O2
-
Streptomyces antibioticus ?
-
?
catechol + O2
-
Streptomyces griseus subsp. griseus ?
-
?
ferrocyanide + O2
-
Streptomyces antibioticus ?
-
?
L-DOPA + O2
-
Streptomyces antibioticus ?
-
?
L-DOPA + O2
-
Streptomyces griseus subsp. griseus ?
-
?
protocatechuic acid + O2
-
Streptomyces griseus subsp. griseus ?
-
?
thiophenol + O2
-
Streptomyces antibioticus ?
-
?

Synonyms

Synonyms Comment Organism
2-aminophenol:oxygen oxidoreductase
-
Streptomyces antibioticus
2-aminophenol:oxygen oxidoreductase
-
Trametes coccinea
2-aminophenol:oxygen oxidoreductase
-
Tecoma stans
2-aminophenol:oxygen oxidoreductase
-
Bauhinia monandra
2-aminophenol:oxygen oxidoreductase
-
Streptomyces griseus subsp. griseus
esophenoxazine synthase
-
Streptomyces antibioticus
esophenoxazine synthase
-
Trametes coccinea
esophenoxazine synthase
-
Tecoma stans
esophenoxazine synthase
-
Bauhinia monandra
esophenoxazine synthase
-
Streptomyces griseus subsp. griseus
GriF
-
Streptomyces griseus subsp. griseus
isophenoxazine synthase
-
Streptomyces antibioticus
isophenoxazine synthase
-
Trametes coccinea
isophenoxazine synthase
-
Tecoma stans
isophenoxazine synthase
-
Bauhinia monandra
isophenoxazine synthase
-
Streptomyces griseus subsp. griseus
o-aminophenol oxidase
-
Streptomyces antibioticus
o-aminophenol oxidase
-
Trametes coccinea
o-aminophenol oxidase
-
Tecoma stans
o-aminophenol oxidase
-
Bauhinia monandra
o-aminophenol oxidase
-
Streptomyces griseus subsp. griseus
o-aminophenol:O2 oxidoreductase
-
Streptomyces antibioticus
o-aminophenol:O2 oxidoreductase
-
Trametes coccinea
o-aminophenol:O2 oxidoreductase
-
Tecoma stans
o-aminophenol:O2 oxidoreductase
-
Bauhinia monandra
o-aminophenol:O2 oxidoreductase
-
Streptomyces griseus subsp. griseus
oxidase, o-aminophenol
-
Streptomyces antibioticus
oxidase, o-aminophenol
-
Trametes coccinea
oxidase, o-aminophenol
-
Tecoma stans
oxidase, o-aminophenol
-
Bauhinia monandra
oxidase, o-aminophenol
-
Streptomyces griseus subsp. griseus
phenoxazinone synthase
-
Streptomyces antibioticus
phenoxazinone synthase
-
Trametes coccinea
phenoxazinone synthase
-
Tecoma stans
phenoxazinone synthase
-
Bauhinia monandra
phenoxazinone synthase
-
Streptomyces griseus subsp. griseus
PHS
-
Streptomyces antibioticus
PHS
-
Trametes coccinea
PHS
-
Tecoma stans
PHS
-
Bauhinia monandra
PHS
-
Streptomyces griseus subsp. griseus
PhsA
-
Streptomyces antibioticus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
40
-
-
Bauhinia monandra
42
-
-
Streptomyces antibioticus
45
-
-
Tecoma stans
55
-
-
Streptomyces griseus subsp. griseus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5 5.2
-
Streptomyces antibioticus
6.2
-
-
Tecoma stans
6.2
-
-
Bauhinia monandra
8.5 10.5
-
Streptomyces griseus subsp. griseus

Cofactor

Cofactor Comment Organism Structure
FAD
-
Tecoma stans
additional information no cofactor required Bauhinia monandra
riboflavin 5'-phosphate
-
Trametes coccinea

Expression

Organism Comment Expression
Streptomyces antibioticus gene expression is subject to glucose repression up

General Information

General Information Comment Organism
physiological function GriF plays a role in the biosynthesis of the antibiotic grixazone Streptomyces griseus subsp. griseus
physiological function PhsA plays a role in pigment production Trametes coccinea
physiological function PhsA plays a role in spore coat pigmentation and melanin production Streptomyces antibioticus
physiological function the enzyme plays a role in atechol production Bauhinia monandra