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Literature summary for 1.11.1.10 extracted from
- Chloroperoxidase-Catalyzed Achmatowicz Rearrangements (2018), Eur. J. Org. Chem., 2018, 2717-2725 .
No PubMed abstract available
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| RH + chloride + H2O2 | Leptoxyphium fumago | - |
RCl + 2 H2O | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Leptoxyphium fumago | P04963 | Caldariomyces fumago | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | chloroperoxidase from Caldariomyces fumago catalyzes the selective oxidation of furfuryl alcohols in an Achmatowicz-type ring expansion. In combination with glucose oxidase as oxygen-activating biocatalyst, a purely enzymatic, aerobic protocol for the synthesis of 6-hydroxypyranone building blocks is obtained. Thanks to an only modest stereochemical bias of the oxygenating heme protein, optically active alcohols of either configuration are converted without a significant mismatch opening up opportunities for enantioselective multienzymatic cascades. Balancing the oxidase-driven aerobic activation, extended enzyme half-lives and productive conversion of poorly soluble and slowly reacting substrates can be achieved with high yields of the six-membered O-heterocycles. The chloroperoxidase from Caldariomyces fumago (CPO) acts as peroxidase-P450 functional hybrid. Enantiodiscrimination in the oxidative conversion of racemic furfuryl alcohols by enzyme CPO in a coupled assay with the glucose oxidase (GOx) from Aspergillus niger, substrate specificity, overview | Leptoxyphium fumago | ? | - |
- |
|
| RH + chloride + H2O2 | - |
Leptoxyphium fumago | RCl + 2 H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| chloroperoxidase | - |
Leptoxyphium fumago |
| CPO | - |
Leptoxyphium fumago |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | 40 | assay at | Leptoxyphium fumago |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 4.5 | 7 | assay at | Leptoxyphium fumago |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| heme | - |
Leptoxyphium fumago | |
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