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Literature summary for 1.11.1.11 extracted from
- Ascorbate peroxidase, a key molecule regulating amphotericin B resistance in clinical isolates of Leishmania donovani (2014), Antimicrob. Agents Chemother., 58, 6172-6184 .
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| modeling of structure based on Leishmania major peroxidase, PDB code 3RIV_A. Residues Glu133, Val127, and Ser301 amino acids may play a key role in the inhibition | Leishmania donovani |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Leishmania donovani | H6V7N3 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| APX | - |
Leishmania donovani |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | constitutive overexpression of APx in an amphotericin B-resistant strain prevents cells from the deleterious effect of oxidative stress, i.e., mitochondrial dysfunction and cellular death induced by amphotericin B | Leishmania donovani |
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Release 2023.1 (January 2023)
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