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Literature summary for 1.11.1.12 extracted from

  • Nomura, K.; Imai, H.; Koumura, T.; Kobayashi, T.; Nakagawa, Y.
    Mitochondrial phospholipid hydroperoxide glutathione peroxidase inhibits the release of cytochrome c from mitochondria by suppressing the peroxidation of cardiolipin in hypoglycaemia-induced apoptosis (2000), Biochem. J., 351, 183-193.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression vector encoding mitochondrial enzyme for overexpression in (RBL)2H3 cell line Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information (RBL)2H3 cell line stably overexpressing mitochondrial phospholipid hydroperoxide glutathione peroxidase from transfected expression plasmid Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glutathione + lipid hydroperoxide Rattus norvegicus
-
glutathione disulfide + lipid + H2O
-
?
additional information Rattus norvegicus mitochondrial enzyme inhibits the release of cytochrome c from mitochondria by suppressing the peroxidation of cardiolipin in hypoglycaemia-induced apoptosis ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leukemia cell basophil leucemia cell line S1 wild-type cell line and (RBL)2H3 cell line overexpressing mitochondrial phospholipid hydroperoxide glutathione peroxidase Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione + cardiolipin
-
Rattus norvegicus ?
-
?
glutathione + lipid hydroperoxide
-
Rattus norvegicus glutathione disulfide + lipid + H2O
-
?
glutathione + tert-butyl hydroperoxide
-
Rattus norvegicus ?
-
?
additional information mitochondrial enzyme inhibits the release of cytochrome c from mitochondria by suppressing the peroxidation of cardiolipin in hypoglycaemia-induced apoptosis Rattus norvegicus ?
-
?