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Literature summary for 1.11.1.12 extracted from
- Mitochondria-specific transgenic overexpression of phospholipid hydroperoxide glutathione peroxidase (GPx4) attenuates ischemia/reperfusion-associated cardiac dysfunction (2008), Free Radic. Biol. Med., 45, 855-865.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Mus musculus | 5739 | - |
| mitochondrion | transgenic mice in which PHGPx is overexpressed solely in the mitochondrion. Mitochondria-specific GPx4 overexpression protects cardiac contractile function and preserves electron transport chain complex activities following ischemia/reperfusion | Mus musculus | 5739 | - |
| additional information | not detected in the nucleus | Mus musculus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
| Mus musculus | O70325 | transgenic mice in which PHGPx is overexpressed solely in the mitochondrion | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glutathione + L-alpha-phosphatidylcholine hydroperoxide | L-alpha-phosphatidylcholine hydroperoxide is a specific substrate of GPx4 | Mus musculus | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GPx4 | - |
Mus musculus |
| PHGPX | - |
Mus musculus |
| phospholipid hydroperoxide glutathione peroxidase | - |
Mus musculus |
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Release 2023.1 (January 2023)
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