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Literature summary for 1.11.1.12 extracted from

  • Ding, W.Q.; Lind, S.E.
    Phospholipid hydroperoxide glutathione peroxidase plays a role in protecting cancer cells from docosahexaenoic acid-induced cytotoxicity (2007), Mol. Cancer Ther., 6, 1467-1474.
    View publication on PubMed
Search for more literature for 1.11.1.12

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
A2780/CP70 cell knockdown of GPx-4 by small interfering RNA technique in a human ovarian cancer cell line significantly enhances the cytotoxic effect of docosahexaenoic acid in a time- and concentration-dependent manner. This cytotoxic effect of docosahexaenoic acid is reversed by pretreatment with vitamin E, suggesting that the enhanced toxicity ofGPx-4 knockdown is due to changes in the ability of the cells to handle oxidative stress Homo sapiens
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C81-61 cell treatment with docosahexaenoic acid results in 95% decrease in GPx-4 level Homo sapiens
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HL-60 cell treatment with docosahexaenoic acid results in 60% decrease in GPx-4 level Homo sapiens
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HT-29 cell treatment with docosahexaenoic acid results in 90% decrease in GPx-4 level Homo sapiens
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MCF-7 cell treatment with docosahexaenoic acid results in 90% decrease in GPx-4 level Homo sapiens
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MM1.R cell treatment with docosahexaenoic acid results in 60% decrease in GPx-4 level Homo sapiens
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MM1.S cell treatment with docosahexaenoic acid results in 21% decrease in GPx-4 level Homo sapiens
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PANC-1 cell treatment with docosahexaenoic acid results in 95% decrease in GPx-4 level Homo sapiens
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RAJI cell treatment with docosahexaenoic acid results in 85% decrease in GPx-4 level Homo sapiens
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Synonyms

Synonyms Comment Organism
GPx-4
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 Homo sapiens