Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.11.1.12 extracted from

  • Conrad, M.
    Transgenic mouse models for the vital selenoenzymes cytosolic thioredoxin reductase, mitochondrial thioredoxin reductase and glutathione peroxidase 4 (2009), Biochim. Biophys. Acta, 1790, 1575-1585.
    View publication on PubMed
Search for more literature for 1.11.1.12

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-
mitochondrion
-
 Mus musculus 5739
-
nucleus
-
 Mus musculus 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
selenium
-
 Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
20000
-
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glutathione + a lipid hydroperoxide Mus musculus
-
 glutathione disulfide + lipid + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Mus musculus
-
MEF cell
-
 Mus musculus
-
spermatozoon
-
 Mus musculus
-
testis
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione + a lipid hydroperoxide
-
 Mus musculus glutathione disulfide + lipid + H2O
-
 ?
additional information preferred substrates are found to be hydroperoxide groups of phosphatidylcholine and on cumene and t-butyl hydroperoxides Mus musculus ?
-
 ?

Subunits

Subunits Comment Organism
monomer
-
 Mus musculus

Synonyms

Synonyms Comment Organism
glutathione peroxidase 4
-
 Mus musculus
GPx4
-
 Mus musculus
PHGPX
-
 Mus musculus
phospholipid hydroperoxide glutathione peroxidase
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
glutathione
-
 Mus musculus