Application | Comment | Organism |
---|---|---|
medicine | the enzyme activates the pro-antitubercular drug isoniazid | Mycobacterium tuberculosis |
Protein Variants | Comment | Organism |
---|---|---|
H108L | the mutant shows decreased catalase catalytic efficiency compared to the wild type enzyme | Mycobacterium tuberculosis |
W107F | the mutant shows decreased catalase catalytic efficiency compared to the wild type enzyme | Mycobacterium tuberculosis |
W107F/W321F | the mutant shows decreased catalase catalytic efficiency compared to the wild type enzyme | Mycobacterium tuberculosis |
W321F | the mutant shows decreased catalase catalytic efficiency compared to the wild type enzyme | Mycobacterium tuberculosis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.11 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | peroxidatic activity, wild type enzyme, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
0.32 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | peroxidatic activity, mutant enzyme W107F/W321F, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
0.36 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | peroxidatic activity, mutant enzyme W321F, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
0.47 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | peroxidatic activity, mutant enzyme W107F, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
1.6 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | peroxidatic activity, mutant enzyme H108L, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
5.7 | - |
tert-butyl hydroperoxide | peroxidatic activity, mutant enzyme W107F, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
12.7 | - |
tert-butyl hydroperoxide | peroxidatic activity, mutant enzyme H108L, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
15.5 | - |
tert-butyl hydroperoxide | peroxidatic activity, mutant enzyme W107F/W321F, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
31.5 | - |
H2O2 | catalatic activity, mutant enzyme W107F, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
32.1 | - |
H2O2 | catalatic activity, mutant enzyme W321F, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
33 | - |
H2O2 | catalatic activity, mutant enzyme W107F/W321F, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
42.6 | - |
H2O2 | catalatic activity, wild type enzyme, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
54.9 | - |
H2O2 | catalatic activity, mutant enzyme H108L, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
91.2 | - |
tert-butyl hydroperoxide | peroxidatic activity, mutant enzyme W321F, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
97.9 | - |
tert-butyl hydroperoxide | peroxidatic activity, wild type enzyme, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) + tert-butyl hydroperoxide | - |
Mycobacterium tuberculosis | oxidized 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) + ? | - |
? | |
H2O2 | - |
Mycobacterium tuberculosis | O2 + H2O | - |
? | |
o-dianisidine + H2O2 | - |
Mycobacterium tuberculosis | oxidized o-dianisidine + H2O | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.34 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | peroxidatic activity, mutant enzyme H108L, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
0.37 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | peroxidatic activity, mutant enzyme W321F, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
0.72 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | peroxidatic activity, wild type enzyme, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
2.4 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | peroxidatic activity, mutant enzyme W107F, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
4.8 | - |
H2O2 | catalatic activity, mutant enzyme W107F, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
5.4 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | peroxidatic activity, mutant enzyme W107F/W321F, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
7.7 | - |
H2O2 | catalatic activity, mutant enzyme W107F/W321F, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
12 | - |
H2O2 | catalatic activity, mutant enzyme H108L, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
2300 | - |
H2O2 | catalatic activity, mutant enzyme W321F, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
6800 | - |
H2O2 | catalatic activity, wild type enzyme, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | heme-dependent enzyme | Mycobacterium tuberculosis |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.014 | - |
tert-butyl hydroperoxide | peroxidatic activity, mutant enzyme W321F, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
0.028 | - |
tert-butyl hydroperoxide | peroxidatic activity, mutant enzyme H108L, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
0.029 | - |
tert-butyl hydroperoxide | peroxidatic activity, wild type enzyme, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
0.15 | - |
H2O2 | catalatic activity, mutant enzyme W107F, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
0.21 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | peroxidatic activity, mutant enzyme H108L, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
0.22 | - |
H2O2 | catalatic activity, mutant enzyme H108L, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
0.23 | - |
H2O2 | catalatic activity, mutant enzyme W107F/W321F, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
0.42 | - |
tert-butyl hydroperoxide | peroxidatic activity, mutant enzyme W107F, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
0.48 | - |
tert-butyl hydroperoxide | peroxidatic activity, mutant enzyme W107F/W321F, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
1 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | peroxidatic activity, mutant enzyme W321F, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
5.1 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | peroxidatic activity, mutant enzyme W107F, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
6.3 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | peroxidatic activity, wild type enzyme, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
17 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | peroxidatic activity, mutant enzyme W107F/W321F, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
73 | - |
H2O2 | catalatic activity, mutant enzyme W321F, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis | |
160 | - |
H2O2 | catalatic activity, wild type enzyme, in 10 mM KH2PO4/K2HPO4, pH 6.0, at 25°C | Mycobacterium tuberculosis |