Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli strain UM255 | Mycobacterium tuberculosis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.96 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | peroxidatic activity, using tert-butyl hydroperoxide as cosubstrate, in 10 mM K2HPO4/KH2PO4 (pH 7.5), at 25°C | Mycobacterium tuberculosis | |
30 | - |
H2O2 | catalatic activity, in 10 mM K2HPO4/KH2PO4 (pH 7.5), at 25°C | Mycobacterium tuberculosis |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
80000 | - |
2 * 80000, SDS-PAGE | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Purification (Comment) | Organism |
---|---|
DEAE-Sepharose column chromatography, Mono Q column chromatography, and Superdex 200 gel filtration | Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O2 | - |
Mycobacterium tuberculosis | oxidized 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O | - |
? | |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) + tert-butyl hydroperoxide | - |
Mycobacterium tuberculosis | oxidized 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) + ? | - |
? | |
H2O2 | - |
Mycobacterium tuberculosis | O2 + H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | 2 * 80000, SDS-PAGE | Mycobacterium tuberculosis |
Synonyms | Comment | Organism |
---|---|---|
KatG | - |
Mycobacterium tuberculosis |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
4.5 | - |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) | peroxidatic activity, using tert-butyl hydroperoxide as cosubstrate, in 10 mM K2HPO4/KH2PO4 (pH 7.5), at 25°C | Mycobacterium tuberculosis | |
2300 | - |
H2O2 | catalatic activity, in 10 mM K2HPO4/KH2PO4 (pH 7.5), at 25°C | Mycobacterium tuberculosis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | the enzyme contains approximately 0.5 heme per dimer | Mycobacterium tuberculosis |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Mycobacterium tuberculosis | isoelectric focusing | 3.8 | 3.7 |
General Information | Comment | Organism |
---|---|---|
physiological function | catalase-peroxidase confers isoniazid (isonicotinic acid hydrazide) sensitivity in Mycobacterium tuberculosis | Mycobacterium tuberculosis |