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Literature summary for 1.11.1.23 extracted from

  • Huang, H.; Chang, W.C.; Lin, G.M.; Romo, A.; Pai, P.J.; Russell, W.K.; Russell, D.H.; Liu, H.W.
    Mechanistic consequences of chiral radical clock probes: analysis of the mononuclear non-heme iron enzyme HppE with 2-hydroxy-3-methylenecyclopropyl radical clock substrates (2014), J. Am. Chem. Soc., 136, 2944-2947.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
[(2R)-2-hydroxy-2-[(1S)-2-methylidenecyclopropyl]ethyl]phosphonate highly effective inhibitor Streptomyces wedmorensis

Metals/Ions

Metals/Ions Comment Organism Structure
Iron a mononuclear non-heme iron enzyme Streptomyces wedmorensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(R)-2-hydroxypropylphosphonate + H2O2 Streptomyces wedmorensis
-
2-oxo-propylphosphonic acid + H2O
-
?
(S)-2-hydroxypropylphosphonate + H2O2 Streptomyces wedmorensis
-
(1R,2S)-1,2-epoxypropylphosphonate + H2O
-
?

Organism

Organism UniProt Comment Textmining
Streptomyces wedmorensis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2-cyclopropyl-2-oxoethyl)phosphonate + H2O2
-
Streptomyces wedmorensis ?
-
?
(R)-2-hydroxypropylphosphonate + H2O2
-
Streptomyces wedmorensis 2-oxo-propylphosphonic acid + H2O
-
?
(S)-2-hydroxypropylphosphonate + H2O2
-
Streptomyces wedmorensis (1R,2S)-1,2-epoxypropylphosphonate + H2O
-
?
[(2R)-2-cyclopropyl-2-hydroxyethyl]phosphonate + H2O2
-
Streptomyces wedmorensis ?
-
?
[(2R)-2-hydroxy-2-[(1R)-2-methylidenecyclopropyl]ethyl]phosphonate + H2O2
-
Streptomyces wedmorensis ?
-
?
[(2R)-2-hydroxy-2-[(1S)-2-methylidenecyclopropyl]ethyl]phosphonate + H2O2
-
Streptomyces wedmorensis ?
-
?
[(2R)-3-cyclopropyloxiran-2-yl]phosphonate + H2O2
-
Streptomyces wedmorensis ?
-
?
[(2R,3S)-3-[(1R)-2-methylidenecyclopropyl]oxiran-2-yl]phosphonate + H2O2
-
Streptomyces wedmorensis ?
-
?
[(2R,3S)-3-[(1S)-2-methylidenecyclopropyl]oxiran-2-yl]phosphonate + H2O2
-
Streptomyces wedmorensis ?
-
?
[(2S)-2-cyclopropyl-2-hydroxyethyl]phosphonate + H2O2
-
Streptomyces wedmorensis ?
-
?
[(2S)-2-hydroxy-2-[(1R)-2-methylidenecyclopropyl]ethyl]phosphonic acid + H2O2
-
Streptomyces wedmorensis ?
-
?
[2-[(1S)-2-methylidenecyclopropyl]-2-oxoethyl]phosphonate + H2O2
-
Streptomyces wedmorensis ?
-
?

Synonyms

Synonyms Comment Organism
HppE
-
Streptomyces wedmorensis