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Literature summary for 1.11.1.24 extracted from
- 2-Cys peroxiredoxin PfTrx-Px1 is involved in the antioxidant defence of Plasmodium falciparum (2003), Mol. Biochem. Parasitol., 130, 75-81.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00078 | - |
H2O2 | pH 7.6, 30°C | Plasmodium falciparum |  |
| 0.0189 | - |
thioredoxin | pH 7.6, 30°C | Plasmodium falciparum | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 400000 | - |
gel filtration | Plasmodium falciparum |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Plasmodium falciparum | after subjection to exogenous and endogenous oxidative stress, the Plasmodium falciparum blood stage form shows a marked elevation of PfTrx-Px1 mRNA and protein levels consistent with the structure of related proteins | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Plasmodium falciparum | - |
3D7 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| H2O2 + reduced thioredoxin | ping-pong kinetics | Plasmodium falciparum | H2O + oxidized thioredoxin | - |
? | |
| additional information | after subjection to exogenous and endogenous oxidative stress, the Plasmodium falciparum blood stage form shows a marked elevation of PfTrx-Px1 mRNA and protein levels consistent with the structure of related proteins | Plasmodium falciparum | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| decamer | consisting of pentamers of homodimers that have a doughnut-like shape | Plasmodium falciparum |
| More | no dimeric form detectable | Plasmodium falciparum |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 2-Cys peroxiredoxin | - |
Plasmodium falciparum |
| PfTrx-Px1 | - |
Plasmodium falciparum |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.67 | - |
H2O2 | pH 7.6, 30°C | Plasmodium falciparum | |
| 9.65 | - |
thioredoxin | pH 7.6, 30°C | Plasmodium falciparum | |
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