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Literature summary for 1.11.1.24 extracted from

  • Nickel, C.; Trujillo, M.; Rahlfs, S.; Deponte, M.; Radi, R.; Becker, K.
    Plasmodium falciparum 2-Cys peroxiredoxin reacts with plasmoredoxin and peroxynitrite (2005), Biol. Chem., 386, 1129-1136.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
C170A kcat/Km of mutant enzyme is reduced for thioredoxin as a substrate approximately 50fold. In contrast to the wildtype enzyme, covalently linked dimers are not formed Plasmodium falciparum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information
-
Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Plasmodium falciparum the enzyme is involved in the detoxification of reactive oxygen species and of reactive nitrogen species ?
-
?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
H2O2 + reduced plasmoredoxin
-
Plasmodium falciparum H2O + oxidized plasmoredoxin
-
?
H2O2 + reduced thioredoxin
-
Plasmodium falciparum H2O + oxidized thioredoxin
-
?
additional information the enzyme is involved in the detoxification of reactive oxygen species and of reactive nitrogen species Plasmodium falciparum ?
-
?
additional information PfTPx1 also possesses peroxynitrite reductase activity Plasmodium falciparum ?
-
?

Subunits

Subunits Comment Organism
dimer
-
Plasmodium falciparum

Synonyms

Synonyms Comment Organism
2-Cys peroxiredoxin
-
Plasmodium falciparum
TPx1
-
Plasmodium falciparum