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Literature summary for 1.11.1.24 extracted from

  • Lee, W.; Choi, K.S.; Riddell, J.; Ip, C.; Ghosh, D.; Park, J.H.; Park, Y.M.
    Human peroxiredoxin 1 and 2 are not duplicate proteins: the unique presence of Cys83 in Prx1 underscores the structural and functional differences between Prx1 and Prx2 (2007), J. Biol. Chem., 282, 22011-22022.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapour diffusion method with 100 mM citrate (pH 4.6) and 10% polyethylene glycol Homo sapiens

Protein Variants

Protein Variants Comment Organism
C83S increased activity compared to wild type Prx1 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
H2O2 highly susceptible to inactivation by H2O2; highly susceptible to inactivation by H2O2 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
43630
-
Prx2, Q-TOF mass spectrometry Homo sapiens
219700
-
Prx1, Q-TOF mass spectrometry Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P32119
-
-
Homo sapiens Q06830
-
-

Purification (Commentary)

Purification (Comment) Organism
DEAE-Sepharose column chromatography, SP-Sepharose column chromatography, and Superdex 200 gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
H2O2 + reduced dithiothreitol
-
Homo sapiens H2O + oxidized dithiothreitol
-
?

Subunits

Subunits Comment Organism
decamer Prx1, X-ray crystallography Homo sapiens
dimer Prx2, X-ray crystallography Homo sapiens

Synonyms

Synonyms Comment Organism
peroxiredoxin 1
-
Homo sapiens
peroxiredoxin 2
-
Homo sapiens
Prx1
-
Homo sapiens
Prx2
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
thioredoxin
-
Homo sapiens