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Literature summary for 1.11.1.24 extracted from

  • Bae, J.Y.; Ahn, S.J.; Han, W.; Noh, D.Y.
    Peroxiredoxin I and II inhibit H2O2-induced cell death in MCF-7 cell lines (2007), J. Cell. Biochem., 101, 1038-1045.
    View publication on PubMed
Search for more literature for 1.11.1.24

Activating Compound

Activating Compound Comment Organism Structure
H2O2 treatment of with H2O2 results in the dose-dependent expressions of Prx I at protein and mRNA levels Homo sapiens
H2O2 treatment of with H2O2 results in the dose-dependent expressions of Prx II at protein and mRNA levels Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
H2O2 significant reductions in Prx II is detected at H2O2 concentrations above 0.6 mM; significant reductions in Prx I is detected at H2O2 concentrations above 0.6 mM Homo sapiens
additional information H2O2 does not cause dose-dependent reduction in expression of isoform Prx IV; H2O2 does not cause dose-dependent reduction in expression of isoform Prx V Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P30044
-
-
Homo sapiens P32119
-
-
Homo sapiens Q06830
-
-
Homo sapiens Q13162
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MCF-10A cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
H2O2 + reduced thioredoxin
-
 Homo sapiens H2O + oxidized thioredoxin
-
 ?

Synonyms

Synonyms Comment Organism
Prx I isozyme Homo sapiens
Prx II isozyme Homo sapiens
PRx IV isozyme Homo sapiens
Prx V isozyme Homo sapiens

Cofactor

Cofactor Comment Organism Structure
thioredoxin
-
 Homo sapiens