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Literature summary for 1.11.1.24 extracted from

  • Hugo, M.; Turell, L.; Manta, B.; Botti, H.; Monteiro, G.; Netto, L.E.; Alvarez, B.; Radi, R.; Trujillo, M.
    Thiol and sulfenic acid oxidation of AhpE, the one-cysteine peroxiredoxin from Mycobacterium tuberculosis: kinetics, acidity constants, and conformational dynamics (2009), Biochemistry, 48, 9416-9426.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Mycobacterium tuberculosis

General Stability

General Stability Organism
addition of 1 mM N-acetylcysteine to AhpE treated with equimolar H2O2 results in a destabilization of the dimer, leading to lower molecular weight species Mycobacterium tuberculosis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
19320
-
electrospray ionization mass spectrometry Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
H2O2 + reduced thioredoxin
-
Mycobacterium tuberculosis H2O + oxidized thioredoxin
-
?
peroxynitrite + reduced thioredoxin AhpE reduces peroxynitrite 2 orders of magnitude faster than H2O2 Mycobacterium tuberculosis ?
-
?

Synonyms

Synonyms Comment Organism
AhpE a 1-Cys peroxiredoxin Mycobacterium tuberculosis
alkyl hydroperoxide reductase
-
Mycobacterium tuberculosis
Rv2238c
-
Mycobacterium tuberculosis

pH Stability

pH Stability pH Stability Maximum Comment Organism
4.5
-
AhpE is unstable and precipitates under low pH conditions (below pH 4.5) Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
thioredoxin
-
Mycobacterium tuberculosis