Literature summary for 1.11.1.24 extracted from

Perez-Perez, M.E.; Mata-Cabana, A.; Sanchez-Riego, A.M.; Lindahl, M.; Florencio, F.J.
A comprehensive analysis of the peroxiredoxin reduction system in the cyanobacterium Synechocystis sp. strain PCC 6803 reveals that all five peroxiredoxins are thioredoxin dependent (2009), J. Bacteriol., 191, 7477-7489 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Synechocystis sp. PCC 6803

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.00074	-	thioredoxin Q	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803
0.0009	-	thioredoxin A	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803
0.0021	-	thioredoxin Q	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803
0.00218	-	thioredoxin B	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803
0.0026	-	thioredoxin B	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803
0.0026	-	thioredoxin Q	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803
0.0028	-	thioredoxin Q	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803
0.0029	-	thioredoxin B	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803
0.0046	-	thioredoxin A	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803
0.0066	-	thioredoxin A	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803
0.0096	-	thioredoxin A	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803
0.0122	-	thioredoxin A	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803
0.0173	-	thioredoxin B	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803
0.0208	-	thioredoxin B	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803

Organism

Organism	UniProt	Comment	Textmining
Synechocystis sp. PCC 6803	P72697	-	-
Synechocystis sp. PCC 6803	P72719	-	-
Synechocystis sp. PCC 6803	P73263	-	-
Synechocystis sp. PCC 6803	P73728	-	-
Synechocystis sp. PCC 6803	Q55624	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Synechocystis sp. PCC 6803

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
thioredoxin A + cumene hydroperoxide	-	Synechocystis sp. PCC 6803	thioredoxin A disulfide + H2O + cumene hydroxide	-	?
thioredoxin A + H2O2	-	Synechocystis sp. PCC 6803	thioredoxin A disulfide + 2 H2O	-	?
thioredoxin A + tert-butyl hydroperoxide	-	Synechocystis sp. PCC 6803	thioredoxin A disulfide + H2O + tert-butyl alcohol	-	?
thioredoxin B + H2O2	-	Synechocystis sp. PCC 6803	thioredoxin B disulfide + 2 H2O	-	?
thioredoxin Q + H2O2	-	Synechocystis sp. PCC 6803	thioredoxin Q disulfide + 2 H2O	-	?

Synonyms

Synonyms	Comment	Organism
1-Cys Prx	-	Synechocystis sp. PCC 6803
2-Cys Prx	-	Synechocystis sp. PCC 6803
Prx Q1	-	Synechocystis sp. PCC 6803
Prx Q2	-	Synechocystis sp. PCC 6803
PrxII	-	Synechocystis sp. PCC 6803
sll0221	-	Synechocystis sp. PCC 6803
sll0755	-	Synechocystis sp. PCC 6803
sll1621	-	Synechocystis sp. PCC 6803
slr0242	-	Synechocystis sp. PCC 6803
slr1198	-	Synechocystis sp. PCC 6803

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
0.009	-	thioredoxin B	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803
0.01	-	thioredoxin A	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803
0.01	-	thioredoxin Q	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803
0.015	-	thioredoxin A	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803
0.045	-	thioredoxin B	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803
0.063	-	thioredoxin Q	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803
0.072	-	thioredoxin B	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803
0.079	-	thioredoxin Q	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803
0.092	-	thioredoxin A	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803
0.099	-	thioredoxin A	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803
0.212	-	thioredoxin B	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803

Expression

Organism	Comment	Expression
Synechocystis sp. PCC 6803	following the addition of 1 mM hydrogen peroxide to Synechocystis cultures, the transcript level of the gene decreases during the first 15 min and thereafter increases to the initial levels	down
Synechocystis sp. PCC 6803	following the addition of 1 mM hydrogen peroxide to Synechocystis cultures, the transcript level of the gene decreases during the first 15 min and thereafter increases to the initial levels	up
Synechocystis sp. PCC 6803	following the addition of 1 mM hydrogen peroxide to Synechocystis cultures, the transcript level of the gene decreases during the first 15 min and thereafter increases to the initial levels. Induction of the 2-cys prx gene in response to high light intensity	up
Synechocystis sp. PCC 6803	following the addition of 1 mM hydrogen peroxide to Synechocystis cultures, the transcript level of the gene decreases during the first 15 min and thereafter increases to the initial levels. The transcript level of the prxII gene increases during nitrogen starvation	up

kcat/KM [mM/s]

kcat/KM Value [1/mMs^-1]	kcat/KM Value Maximum [1/mMs^-1]	Substrate	Comment	Organism	Structure
2	-	thioredoxin A	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803
2	-	thioredoxin B	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803
3	-	thioredoxin B	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803
6	-	thioredoxin A	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803
9.7	-	thioredoxin B	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803
10	-	thioredoxin A	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803
11	-	thioredoxin A	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803
13	-	thioredoxin B	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803
22	-	thioredoxin A	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803
39	-	thioredoxin Q	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803
54	-	thioredoxin Q	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803
85	-	thioredoxin Q	pH 7.0, temperature not specified in the publication	Synechocystis sp. PCC 6803

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Release 2023.1 (January 2023)