Cloned (Comment) | Organism |
---|---|
His-tagged proteins is expressed in Escherichia coli BL21(DE3) | Vibrio vulnificus |
Protein Variants | Comment | Organism |
---|---|---|
C48S | mutant enzyme does not exhibit activity | Vibrio vulnificus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Vibrio vulnificus | A0A1Z0YU24 | - |
- |
Vibrio vulnificus MO6-24/O | A0A1Z0YU24 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Vibrio vulnificus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutaredoxin 3 + H2O2 | the enzyme is only active when glutaredoxin 3, glutathione, and glutathione reductase are present together as a reducing system | Vibrio vulnificus | glutaredoxin 3 disulfide + 2 H2O | - |
? | |
glutaredoxin 3 + H2O2 | the enzyme is only active when glutaredoxin 3, glutathione, and glutathione reductase are present together as a reducing system | Vibrio vulnificus MO6-24/O | glutaredoxin 3 disulfide + 2 H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | - |
Vibrio vulnificus |
Synonyms | Comment | Organism |
---|---|---|
Grx3/GSH-dependent peroxidase | - |
Vibrio vulnificus |
Prx3 | ambiguous | Vibrio vulnificus |
Organism | Comment | Expression |
---|---|---|
Vibrio vulnificus | the Fe-S cluster regulator IscR senses iron starvation as well as reactive oxygen species and shifts to the Fe-S clusterless apo-form, which leads to the increase of cellular IscR and in turn prx3 expression, contributing to the survival and virulence of Vibrio vulnificus during pathogenesis | up |
General Information | Comment | Organism |
---|---|---|
malfunction | the prx3 mutation impairs growth in the medium containing peroxides and reduces virulence in mice | Vibrio vulnificus |
physiological function | Prx3 is essential for survival under oxidative stress and pathogenesis of Vibrio vulnificus | Vibrio vulnificus |