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Literature summary for 1.11.1.7 extracted from

  • Sliskovic, I.; Abdulhamid, I.; Sharma, M.; Abu-Soud, H.M.
    Analysis of the mechanism by which tryptophan analogs inhibit human myeloperoxidase (2009), Free Radic. Biol. Med., 47, 1005-1013.
    View publication on PubMed
Search for more literature for 1.11.1.7

Inhibitors

Inhibitors Comment Organism Structure
1-methyl-L-tryptophan
-
 Homo sapiens
5-fluoro-L-tryptophan
-
 Homo sapiens
L-tryptophan
-
 Homo sapiens
L-tryptophan benzyl ester
-
 Homo sapiens
Nalpha-methoxycarbonyl-L-tryptophan methyl ester
-
 Homo sapiens
Nalpha-methyl-L-tryptophan
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leukocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Cl- + H2O2
-
 Homo sapiens HOCl + H2O
-
 ?

Synonyms

Synonyms Comment Organism
MPO
-
 Homo sapiens
myeloperoxidase
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000175
-
 at 25°C in 0.2 M sodium phosphate buffer, pH 7.0 Homo sapiens L-tryptophan benzyl ester
0.00035
-
 at 25°C in 0.2 M sodium phosphate buffer, pH 7.0 Homo sapiens Nalpha-methoxycarbonyl-L-tryptophan methyl ester
0.00175
-
 at 25°C in 0.2 M sodium phosphate buffer, pH 7.0 Homo sapiens 1-methyl-L-tryptophan
0.00225
-
 at 25°C in 0.2 M sodium phosphate buffer, pH 7.0 Homo sapiens L-tryptophan
0.00325
-
 at 25°C in 0.2 M sodium phosphate buffer, pH 7.0 Homo sapiens 5-fluoro-L-tryptophan
0.0052
-
 at 25°C in 0.2 M sodium phosphate buffer, pH 7.0 Homo sapiens Nalpha-methyl-L-tryptophan