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Literature summary for 1.11.1.8 extracted from

  • Bresson, D.; Pugniere, M.; Roquet, F.; Rebuffat, S.A.; N-Guyen B.; Cerutti, M.; Guo, J.; McLachlan, S.M.; Rapoport, B.; Estienne, V.; Ruf, J.; Chardes, T.; Peraldi-Roux, S.
    Directed mutagenesis in region 713-720 of human thyroperoxidase assigns 713KFPED717 residues as being involved in the B domain of the discontinuous immunodominant region recognized by human autoantibodies (2004), J. Biol. Chem., 279, 39058-39067.
    View publication on PubMed
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Application

Application Comment Organism
medicine amino acids from TPO region 713-717 are the key residues, recognized by IDR/B-specific anti-TPO autoantibodies in autoimmune thyroid disease. These data are of great importance to rationally design therapeutic peptides able to block undesired autoimmune responses Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens amino acids from TPO region 713-717 are the key residues, recognized by IDR/B-specific anti-TPO autoantibodies in autoimmune thyroid disease ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
thyroid gland
-
 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information amino acids from TPO region 713-717 are the key residues, recognized by IDR/B-specific anti-TPO autoantibodies in autoimmune thyroid disease Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
TPO
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 Homo sapiens